Margolin B H
Environ Health Perspect. 1985 Nov;63:187-94. doi: 10.1289/ehp.8563187.
This paper surveys recent, as yet unpublished, statistical studies arising from research in genetic toxicology within the U.S. National Toxicology Program (NTP). These studies all involve analyses of data from Ames Salmonella/microsome mutagenicity tests, but the statistical methodologies are broadly applicable. Three issues are addressed: First, what is a tenable sampling model for Ames test data, and how does one best test the adequacy of the Poisson sampling assumption? Second, given that nonmonotone dose-response curves are fairly common in the Salmonella assay, what new statistical techniques or modifications of existing ones seem appropriate to accommodate to this reality? Finally, an intriguing question: How can the extensive NTP Ames test data base be used to assess the characteristics of any mutagen-nonmutagen decision rule? The last issue is illustrated with the commonly used "two-times background" rule.
本文概述了美国国家毒理学计划（NTP）内遗传毒理学研究中近期尚未发表的统计研究。这些研究均涉及对鼠伤寒沙门氏菌/微粒体诱变性试验数据的分析，但统计方法具有广泛的适用性。本文探讨了三个问题：第一，鼠伤寒沙门氏菌试验数据的合理抽样模型是什么，如何最好地检验泊松抽样假设的充分性？第二，鉴于沙门氏菌试验中出现非单调剂量反应曲线相当常见，哪些新的统计技术或对现有技术的修改似乎适合适应这一现实？最后，一个有趣的问题：如何利用NTP广泛的鼠伤寒沙门氏菌试验数据库来评估任何诱变剂 - 非诱变剂决策规则的特征？最后一个问题通过常用的“两倍背景”规则进行说明。
