Yan Xiaoyi, Ding Hui, Ren Mengxiao, Zang Lei
The Third Department of Geriatrics, Weifang People's Hospital, Weifang, Shandong, China.
Oncol Rev. 2025 Jul 21;19:1607983. doi: 10.3389/or.2025.1607983. eCollection 2025.
This review aims to explore the mechanisms by which mitophagy contributes to treatment resistance in solid tumors. As advancements in cancer therapies continue to evolve, treatment resistance emerges as a significant barrier to successful tumor management. Mitophagy, a specific form of cellular autophagy, has been implicated in the survival, proliferation, and drug resistance of tumor cells. This article will summarize the latest research findings and analyze how mitophagy impacts the biological characteristics of solid tumors, thereby revealing its potential implications in cancer treatment strategies. By understanding the role of mitophagy in the context of treatment resistance, we may uncover new therapeutic targets and strategies to enhance the efficacy of existing cancer treatments.
本综述旨在探讨线粒体自噬导致实体瘤治疗耐药的机制。随着癌症治疗的不断进步，治疗耐药已成为成功管理肿瘤的重大障碍。线粒体自噬作为细胞自噬的一种特殊形式，与肿瘤细胞的存活、增殖和耐药性有关。本文将总结最新研究成果，并分析线粒体自噬如何影响实体瘤的生物学特性，从而揭示其在癌症治疗策略中的潜在意义。通过了解线粒体自噬在治疗耐药背景下的作用，我们可能会发现新的治疗靶点和策略，以提高现有癌症治疗的疗效。
