Zheng Fumin, Liu Yang, Yang Mei, Yu Xixi, Wang Wanchun
Department of Oral Medicine, Qingdao Stomatological Hospital Affiliated to Qingdao University, Qingdao, Shandong, China.
School of Stomatology, Qingdao University, Qingdao, Shandong, China.
Front Oral Health. 2025 Jul 21;6:1601156. doi: 10.3389/froh.2025.1601156. eCollection 2025.
This case report describes an instance of oral mucosal hypersensitive reaction resembling oral lichenoid reaction (OLR) induced by the use of a whitening toothpaste in a 28-year-old female patient presenting with extensive white hypersensitive reaction on the oral mucosa. The clinical features resembled an oral mucosal hypersensitivity reaction with lichenoid morphology. A detailed history revealed a clear temporal association between the onset of the reaction and the use of whitening toothpaste. Symptoms rapidly improved following discontinuation of the product, and a positive rechallenge test further confirmed the causal relationship. In conjunction with a review of the literature, the potential pathogenic mechanisms of abrasive agents (e.g., calcium carbonate), chemical agents [e.g., hydrogen peroxide (HP), sodium lauryl sulfate (SLS)], and other additives in whitening toothpaste are discussed. This case documents the first confirmed association between whitening toothpaste and an oral mucosal hypersensitivity reaction with lichenoid morphology, highlighting the importance of differentiating hypersensitivity mechanisms in lichenoid-like presentations.
本病例报告描述了一名28岁女性患者，因使用美白牙膏而出现口腔黏膜超敏反应，类似口腔苔藓样反应（OLR），其口腔黏膜出现广泛的白色超敏反应。临床特征类似于具有苔藓样形态的口腔黏膜超敏反应。详细病史显示反应发作与使用美白牙膏之间存在明确的时间关联。停用该产品后症状迅速改善，再次激发试验阳性进一步证实了因果关系。结合文献复习，讨论了美白牙膏中研磨剂（如碳酸钙）、化学剂[如过氧化氢（HP）、月桂醇硫酸酯钠（SLS）]及其他添加剂的潜在致病机制。本病例记录了美白牙膏与具有苔藓样形态的口腔黏膜超敏反应之间首次得到证实的关联，突出了在苔藓样表现中区分超敏机制的重要性。
