Sarwar Muavia, Irfan Hafiz Muhammad, Jabbar Zeeshan, Asim Mulazim Hussain, Hassan Muhammad Sajjad, Nawaz Shoaib
Department of Pharmacology, Faculty of Pharmacy, University of Sargodha, Sargodha, 40100, Punjab, Pakistan.
Punjab University College of Pharmacy, University of the Punjab, Lahore, 54000, Punjab, Pakistan.
Mol Divers. 2025 Aug 5. doi: 10.1007/s11030-025-11305-4.
This study explores the potential of phytochemicals as an innovative and successful strategy for mitigating symptoms of benign prostatic hyperplasia and prostate cancer. Prostate cancer is the most prevalent and second highest cause of mortality for men, with over 121 million cases worldwide. Finding no comprehensive study on the impact of compounds from all phytochemical classes in the perspectives of prostate disorders, this study analyzed data from a variety of investigations, including preclinical studies, in vitro and in vivo experiments, clinical trials, and cell line investigations, as part of a review of the literature. With a focus on mechanisms such as aging and hormonal factor modulation, apoptosis induction, overcoming inflammation, metabolic crisis, and medication resistance while minimizing side effects, the search concentrated on the effects of natural substances on prostate hyperplastic and malignant cells. The sequel of the study is suggestive of strong anti-hyperplastic and anti-cancerous potentials of phytochemicals in prostate cells. These phytochemicals have the capacity to target several pathways, providing a multifaceted approach to the therapy of BPH and prostate cancer. Interestingly, a large number of these substances exhibit negligible side effects, suggesting their possible use in clinical settings. The study unveils the mechanistic role of compounds belonging to various phytochemical classes in improving life quality and longevity in men with BPH and prostate cancer. Besides associating the existing literature, outcomes of the study ignite encouraging prospects towards further advancements in drug discovery and anticipation for prompt therapies.
本研究探讨了植物化学物质作为减轻良性前列腺增生和前列腺癌症状的创新且成功策略的潜力。前列腺癌是男性中最常见且致死率第二高的疾病，全球病例超过1.21亿例。由于未找到关于所有植物化学类别化合物对前列腺疾病影响的全面研究，本研究分析了各种调查的数据，包括临床前研究、体外和体内实验、临床试验以及细胞系研究，作为文献综述的一部分。研究聚焦于衰老和激素因子调节、诱导凋亡、克服炎症、代谢危机和耐药性等机制，同时尽量减少副作用，着重研究天然物质对前列腺增生和恶性细胞的影响。该研究结果表明植物化学物质在前列腺细胞中具有强大的抗增生和抗癌潜力。这些植物化学物质能够靶向多种途径，为良性前列腺增生和前列腺癌的治疗提供了多方面的方法。有趣的是，这些物质中的许多显示出可忽略不计的副作用，表明它们可能用于临床。该研究揭示了不同植物化学类别化合物在改善良性前列腺增生和前列腺癌男性患者生活质量和寿命方面的作用机制。除了关联现有文献外，该研究结果为药物发现的进一步进展和快速治疗的预期带来了令人鼓舞的前景。
