Aja Patrick Maduabuchi, Agu Peter Chinedu, Musyoka Angela Mumbua, Ngwueche Wisdom, Odo Joseph Uche, Alum Esther Ugo, Fasogbon Ilemobayo Victor, Herbert Mbyemeire, Daniel Eze Ejike
Biochemistry Department, Biomedical Sciences Faculty, Kampala International University, Bushenyi, Uganda.
Biochemistry Department, Faculty of Science, Ebonyi State University, Abakaliki, Nigeria.
Am J Mens Health. 2025 May-Jun;19(3):15579883251344571. doi: 10.1177/15579883251344571. Epub 2025 Jun 23.
Prostate-related conditions, including benign prostatic hyperplasia, prostatitis, and prostate cancer, represent significant health concerns, particularly among aging men. This study utilized a comprehensive review of existing literature and case studies to explore the effectiveness of integrative approaches, emphasizing nutrition, exercise, and lifestyle modifications, in managing prostate diseases. Data were collected from peer-reviewed journals, clinical trials, and meta-analyses focusing on dietary patterns, physical activity, and complementary therapies. The findings were synthesized to provide evidence-based recommendations. Results highlight that plant-based diets, rich in fruits, vegetables, whole grains, and healthy fats, demonstrate protective effects against prostate conditions, while diets high in saturated fats and processed foods increase risk. Specific bioactive compounds,such as lycopene, omega-3 fatty acids, and polyphenols, were linked to reduced disease progression. Physical activity emerged as a key component, enhancing hormonal balance, reducing inflammation, and improving survival rates in prostate cancer patients. Aerobic and resistance exercises were particularly effective in mitigating treatment side effects such as fatigue and muscle loss. Stress-reduction techniques, including mindfulness and yoga, alongside moderated alcohol consumption, further improved psychological well-being and overall prostate health. Integrative approaches, combining conventional treatments with holistic care, demonstrated enhanced outcomes by addressing the physical, emotional, and social dimensions of prostate disease. Emerging fields such as nutrigenomics and natural products offer opportunities for personalized interventions, paving the way for innovative management strategies. This study underscores the potential of integrative methods to improve disease outcomes, prevent progression, and enhance the quality of life for men affected by prostate conditions, advocating for their inclusion in prostate disease management protocols.
与前列腺相关的疾病，包括良性前列腺增生、前列腺炎和前列腺癌，是重大的健康问题，在老年男性中尤为突出。本研究通过对现有文献和案例研究进行全面综述，探讨综合方法（强调营养、运动和生活方式改变）在管理前列腺疾病方面的有效性。数据收集自同行评审期刊、临床试验以及聚焦饮食模式、身体活动和补充疗法的荟萃分析。对研究结果进行综合分析以提供基于证据的建议。结果表明，富含水果、蔬菜、全谷物和健康脂肪的植物性饮食对前列腺疾病具有保护作用，而富含饱和脂肪和加工食品的饮食则会增加患病风险。特定的生物活性化合物，如番茄红素、ω-3脂肪酸和多酚，与疾病进展减缓有关。身体活动是一个关键因素，可增强激素平衡、减轻炎症并提高前列腺癌患者的生存率。有氧运动和抗阻运动在减轻疲劳和肌肉流失等治疗副作用方面特别有效。包括正念和瑜伽在内的减压技巧，以及适度饮酒，进一步改善了心理健康和整体前列腺健康。将传统治疗与整体护理相结合的综合方法，通过解决前列腺疾病的身体、情感和社会层面问题，显示出更好的治疗效果。营养基因组学和天然产物等新兴领域为个性化干预提供了机会，为创新管理策略铺平了道路。本研究强调了综合方法在改善疾病预后、预防疾病进展以及提高受前列腺疾病影响男性生活质量方面的潜力，主张将其纳入前列腺疾病管理方案。
