Purkayastha Hrishav Das, Bhattacharjee Abhishek, Swain Ranjit Prasad
Department of Pharmaceutical Sciences, Assam University (A Central University), Silchar-788011, Assam, India.
GITAM School of Pharmacy, GITAM (Deemed to be University), Rushikonda, Visakhapatnam-530045, Andhra Pradesh, India.
Curr Mol Med. 2025 May 2. doi: 10.2174/0115665240378450250410073416.
This review highlights the new healing frontiers opened by herbal preparations rich in punicic acid, as well as ellagic acid, in the management of Lower Urinary Tract Disorders (LUTD). New data prove that these bioactive compounds possess strong anti-inflammatory, antioxidant, and antibacterial properties, and therefore, can be helpful in treating LUTD symptoms such as urgency, frequency, and dysuria. We conducted a comprehensive pharmacological assessment of punicic and ellagic acids aimed at determining their role in bladder health through modulation of inflammatory processes and both alteration and maintenance of urothelium integrity, in addition to obtaining some background information and chemical properties of these acids. Furthermore, we evaluated the findings of clinical and preclinical studies that demonstrated the ability of these formulations to improve the basic functions of the organs in the urinary system and the quality of life of patients. The review also reflects on the use of herbal extracts in combination with current therapies as a synergistic approach, particularly on the healing effects of such combinations and the need for solid clinical evidence to support such claims. This paper focuses on the concept of how LUTDs can be treated safely and effectively without the help of drugs by integrating modern scientific strategies with traditional approaches, which will thus increase the comprehensiveness of treatment in urological care. Future research should focus on improving how well these compounds are absorbed in the body and gathering long-term safety data, with the goal of incorporating them into treatment guidelines.
本综述重点介绍了富含石榴酸以及鞣花酸的草药制剂在治疗下尿路疾病（LUTD）方面开辟的新的治疗前沿。新数据证明，这些生物活性化合物具有强大的抗炎、抗氧化和抗菌特性，因此有助于治疗LUTD的症状，如尿急、尿频和排尿困难。我们对石榴酸和鞣花酸进行了全面的药理学评估，旨在通过调节炎症过程以及改变和维持尿路上皮的完整性来确定它们在膀胱健康中的作用，此外还获取了这些酸的一些背景信息和化学性质。此外，我们评估了临床和临床前研究的结果，这些研究表明这些制剂能够改善泌尿系统器官的基本功能以及患者的生活质量。该综述还思考了将草药提取物与当前疗法联合使用作为一种协同方法的情况，特别是这种联合使用的治疗效果以及需要确凿的临床证据来支持此类说法。本文重点关注如何通过将现代科学策略与传统方法相结合，在无需药物帮助的情况下安全有效地治疗LUTD的理念，这将从而提高泌尿外科护理中治疗的全面性。未来的研究应专注于提高这些化合物在体内的吸收程度，并收集长期安全性数据，目标是将它们纳入治疗指南。
