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儿童和青少年长期新冠症状:一项范围综述

Symptoms of long COVID in children and adolescents: a scoping review.

作者信息

Gusmão Ariel Courbassier Santos de, Scaléa Ana Cristina Ribeiro La, Uehara Silvia Carla da Silva André

机构信息

Universidade Federal de São Carlos, Departamento de Enfermagem, São Carlos, SP, Brazil.

出版信息

Rev Esc Enferm USP. 2025 Aug 4;59:e20240435. doi: 10.1590/1980-220X-REEUSP-2024-0435en. eCollection 2025.

DOI:10.1590/1980-220X-REEUSP-2024-0435en
PMID:40762988
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12330226/
Abstract

OBJECTIVE

To map the symptoms of Long Covid (LC) presented by children and adolescents.

METHOD

This is a scoping review, using the search engines Web of Science, Scopus, Virtual Health Library, and PUBMED, following the principles of the Joanna Briggs Institute.

RESULTS

Sixteen studies were selected, which showed that fatigue, headache, dyspnea, and cough were the most frequent symptoms of LC. There is a tendency for the development of child-adolescent LC related to the increase in age range, and the correlation between LC and predominant sex proved to be inconclusive. The presence of comorbidities, such as obesity, respiratory, neurological and renal diseases, was the most reported and a study showed an association between Covid-19 vaccine protection and LC.

CONCLUSION

This review points to a plurality of symptomatic manifestations of LC in children and adolescents, changing according to age group and health history.

摘要

目的

梳理儿童和青少年出现的长新冠(LC)症状。

方法

这是一项范围综述,遵循乔安娜·布里格斯研究所的原则,使用科学网、Scopus、虚拟健康图书馆和PubMed搜索引擎。

结果

选取了16项研究,这些研究表明疲劳、头痛、呼吸困难和咳嗽是长新冠最常见的症状。长新冠在儿童和青少年中的发展有随年龄范围增加的趋势,且长新冠与主要性别之间的相关性尚无定论。肥胖、呼吸、神经和肾脏疾病等合并症的存在是报告最多的情况,一项研究表明新冠疫苗保护与长新冠之间存在关联。

结论

本综述指出长新冠在儿童和青少年中有多种症状表现,会根据年龄组和健康史而变化。

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本文引用的文献

1
Long COVID in Children and Adolescents: Mechanisms, Symptoms, and Long-Term Impact on Health-A Comprehensive Review.儿童和青少年的长期新冠:机制、症状及对健康的长期影响——全面综述
J Clin Med. 2025 Jan 9;14(2):378. doi: 10.3390/jcm14020378.
2
Characterizing Long COVID in Children and Adolescents.儿童和青少年长期新冠症状的特征分析
JAMA. 2024 Aug 21;332(14):1174-88. doi: 10.1001/jama.2024.12747.
3
[Overview of long COVID in Brazil: a preliminary analysis of a survey to think about health policies].[巴西长期新冠的概述:一项关于思考卫生政策的调查的初步分析]
Cad Saude Publica. 2024 Apr 29;40(4):e00094623. doi: 10.1590/0102-311XPT094623. eCollection 2024.
4
Long-term effects of SARS-CoV-2 infection in hospitalized children: findings from an Italian single-center study.长期随访:意大利单中心研究揭示儿童严重急性呼吸综合征冠状病毒 2 感染的临床转归
Ital J Pediatr. 2024 Feb 14;50(1):27. doi: 10.1186/s13052-024-01596-y.
5
Vaccine Effectiveness Against Long COVID in Children.疫苗对儿童长新冠的有效性。
Pediatrics. 2024 Apr 1;153(4). doi: 10.1542/peds.2023-064446.
6
A Single Center Observational Study on Clinical Manifestations and Associated Factors of Pediatric Long COVID.儿科长新冠的临床表现及相关因素的单中心观察性研究。
Int J Environ Res Public Health. 2023 Sep 21;20(18):6799. doi: 10.3390/ijerph20186799.
7
Youth Mental Health Outcomes up to Two Years After SARS-CoV-2 Infection Long-COVID or Long-Pandemic Syndrome: A Retrospective Cohort Study.新冠病毒感染后长达两年的青少年心理健康结局:长新冠或长疫情综合征:一项回顾性队列研究。
J Adolesc Health. 2023 Oct;73(4):701-706. doi: 10.1016/j.jadohealth.2023.05.022. Epub 2023 Jun 30.
8
Long COVID in children and adolescents: prevalence, clinical manifestations, and management strategies.儿童和青少年的长期新冠:患病率、临床表现及管理策略
Clin Exp Pediatr. 2023 Nov;66(11):465-474. doi: 10.3345/cep.2023.00472. Epub 2023 Jun 19.
9
Long COVID and Hybrid Immunity among Children and Adolescents Post-Delta Variant Infection in Thailand.泰国儿童和青少年在感染德尔塔变异株后的长期新冠症状及混合免疫情况
Vaccines (Basel). 2023 Apr 23;11(5):884. doi: 10.3390/vaccines11050884.
10
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BMJ Case Rep. 2023 May 22;16(5):e255734. doi: 10.1136/bcr-2023-255734.