Di Paolo T, Rouillard C, Bédard P
Eur J Pharmacol. 1985 Nov 5;117(2):197-203. doi: 10.1016/0014-2999(85)90604-1.
Ovariectomized rats injected with 17 beta-estradiol (30 ng, s.c.) showed an increase of the dopamine metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) with no change of dopamine concentrations in the striatum and nucleus accumbens. This increase was observed 30 min after the steroid injection and coincided with peak plasma 17 beta-estradiol concentrations. Plasma prolactin concentrations were not significantly elevated after 30 ng of 17 beta-estradiol. In ovariectomized rats with a unilateral lesion of the entopeduncular nucleus, the same dose of 17 beta-estradiol induced a postural deviation to the lesioned side with a maximum at 30 min. Thus, very small doses of estradiol were able to increase dopamine turnover. This effect was seen within minutes and was relatively short. It is probably non-genomic, presynaptic and similar to the effect of a small dose of a dopamine releasing agent.
注射17β-雌二醇（30纳克，皮下注射）的去卵巢大鼠纹状体和伏隔核中的多巴胺代谢产物二羟基苯乙酸（DOPAC）和高香草酸（HVA）增加，而多巴胺浓度无变化。这种增加在注射类固醇后30分钟观察到，与血浆17β-雌二醇浓度峰值一致。注射30纳克17β-雌二醇后，血浆催乳素浓度未显著升高。在伴有内苍白球核单侧损伤的去卵巢大鼠中，相同剂量的17β-雌二醇在30分钟时诱导向损伤侧的姿势偏差达到最大值。因此，非常小剂量的雌二醇就能增加多巴胺周转率。这种效应在数分钟内出现且持续时间相对较短。它可能是非基因组的、突触前的，并且类似于小剂量多巴胺释放剂的效应。
