Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, United States.
Department of Psychology, University of Kentucky, Lexington, KY, United States.
Front Neuroendocrinol. 2023 Apr;69:101059. doi: 10.1016/j.yfrne.2023.101059. Epub 2023 Feb 7.
Clinically, women appear to be more susceptible to certain aspects of substance use disorders (SUDs). The steroid hormones 17β-estradiol (E2) and progesterone (Pg) have been linked to women-specific drug behaviors. Here, we review clinical and preclinical studies investigating how cycling ovarian hormones affect nicotine-, cocaine-, and opioid-related behaviors. We also highlight gaps in the literature regarding how synthetic steroid hormone use may influence drug-related behaviors. In addition, we explore how E2 and Pg are known to interact in brain reward pathways and provide evidence of how these interactions may influence drug-related behaviors. The synthesis of this review demonstrates the critical need to study women-specific factors that may influence aspects of SUDs, which may play important roles in addiction processes in a sex-specific fashion. It is important to understand factors that impact women's health and may be key to moving the field forward toward more efficacious and individualized treatment strategies.
临床上，女性似乎更容易受到某些物质使用障碍（SUD）的影响。甾体激素 17β-雌二醇（E2）和孕酮（Pg）与女性特有的药物行为有关。在这里，我们回顾了临床和临床前研究，调查了循环卵巢激素如何影响尼古丁、可卡因和阿片类药物相关行为。我们还强调了关于合成甾体激素使用如何影响与药物相关的行为的文献中的空白。此外，我们探讨了 E2 和 Pg 如何在大脑奖励途径中相互作用，并提供了这些相互作用如何影响与药物相关的行为的证据。本综述的综合表明，迫切需要研究可能影响 SUD 某些方面的女性特有的因素，这些因素可能以性别特异性的方式在成瘾过程中发挥重要作用。了解影响女性健康的因素并可能是推动该领域朝着更有效和个体化的治疗策略前进的关键因素非常重要。
