Pasargiklian M, Bianco S, Allegra L, Moavero N E, Petrigni G, Robuschi M, Grugni A
Respiration. 1977;34(2):78-91.
The behaviour of bronchial reactivity to PGF2alpha was studied in asthmatic patients under various experimental conditions. Premedication with aminophylline, i.v., and, to a lesser extent, with DSCG afforded a partial protection, while beclomethasone dipropionate was inactive under this point of view. Diftalone, a new non-steroid anti-inflammatory agent, was well tolerated in 9 aspirin-intolerant asthmatic patients, and did not modify the bronchial response to PGF2alpha which was found to be generally lower then that of other aspirin-tolerant asthmatic patients. PGE 1-2 and DSCG prevented the bronchospasm induced by inhalation or ingestion of acetylsalicylic acid in a small group of patients. Good protection was also reached with PGE1-2 in the exercise-induced bronchospasm.
在不同实验条件下，对哮喘患者支气管对前列腺素F2α（PGF2α）的反应性进行了研究。静脉注射氨茶碱进行预处理，在较小程度上，使用色甘酸钠（DSCG）也能提供部分保护，而从这方面来看，二丙酸倍氯米松则无活性。双氟尼酸，一种新型非甾体抗炎药，在9名阿司匹林不耐受的哮喘患者中耐受性良好，且未改变支气管对PGF2α的反应，发现该反应通常低于其他阿司匹林耐受的哮喘患者。在一小部分患者中，前列腺素E1-2（PGE1-2）和DSCG可预防吸入或摄入乙酰水杨酸引起的支气管痉挛。PGE1-2在运动诱发的支气管痉挛中也能提供良好的保护。
