Smith A P, Cuthbert M F
Adv Prostaglandin Thromboxane Res. 1976;1:449-59.
Although PGE2 and PGF2alpha have potent effects on the human bronchus by aerosol, they are less potent when given by the intravenous route. Prostaglandin E2 may cause bronchoconstriction. Indomethacin had no effect on day-to-day asthmatic symptoms, or challenge-induced asthma, suggesting that prostaglandins are not fundamental to the pathogenesis of asthma.
尽管前列腺素E2（PGE2）和前列腺素F2α（PGF2α）通过气雾剂对人体支气管有显著作用，但经静脉途径给药时作用较弱。前列腺素E2可能会引起支气管收缩。吲哚美辛对日常哮喘症状或激发性哮喘没有影响，这表明前列腺素并非哮喘发病机制的关键因素。
