Arlud Sarnai, Xu Hang, Bai Yu Feng, Bao Narisu, Balnuud Altanhuyag, Wuyun Siriguleng, Xie Nabucha, Tong Narangerili, He Nagongbilige, Wang Wei Wen
Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, No. 16 Lincui Road, Chaoyang District, Beijing, 100101, China.
Department of Mongolian Psychosomatic Medicine, Inner Mongolia International Mongolian Hospital, Hohhot, Inner Mongolia, China.
Sci Rep. 2025 Aug 5;15(1):28619. doi: 10.1038/s41598-025-12649-5.
Psoriasis, a chronic autoimmune skin disease, arises from both genetic predisposition and environmental factors, including Adverse Childhood Experiences (ACEs). This cross-sectional study investigated the association between ACEs, family history, and early-onset psoriasis (≤ 18 years), with particular attention to gender differences. Among 102 psoriasis patients (54 early-onset, 48 late-onset), the early-onset group demonstrated a higher proportion of females, greater prevalence of parental psoriasis, and elevated anxiety levels compared to the late-onset group. However, multivariable regression analysis revealed that parental psoriasis was not significantly associated with early-onset psoriasis. Exposure to three or more ACEs significantly associated with early-onset psoriasis (adjusted OR = 2.61, p = 0.014), with specific associations observed for emotional neglect, domestic violence, and loneliness. Gender-stratified analysis showed a stronger association in females (adjusted OR = 6.609, p = 0.016) than in males (adjusted OR = 2.494, p = 0.115), though no significant gender-ACEs interaction was detected (p = 0.289). These findings demonstrate a gender differences, dose-response relationship between ACEs and early-onset psoriasis, highlighting the potential value of early psychological interventions for at-risk individuals, particularly females with high ACE exposure.
银屑病是一种慢性自身免疫性皮肤病，由遗传易感性和环境因素共同引发，其中包括童年不良经历（ACEs）。这项横断面研究调查了ACEs、家族史与早发性银屑病（≤18岁）之间的关联，特别关注了性别差异。在102例银屑病患者中（54例早发性，48例晚发性），与晚发性组相比，早发性组女性比例更高，父母患银屑病的患病率更高，焦虑水平也更高。然而，多变量回归分析显示，父母患银屑病与早发性银屑病并无显著关联。暴露于三种或更多种ACEs与早发性银屑病显著相关（调整后的比值比=2.61，p=0.014），在情感忽视、家庭暴力和孤独方面存在特定关联。性别分层分析显示，女性（调整后的比值比=6.609，p=0.016）比男性（调整后的比值比=2.494，p=0.115）的关联更强，尽管未检测到显著的性别-ACEs相互作用（p=0.289）。这些发现表明了ACEs与早发性银屑病之间存在性别差异和剂量反应关系，凸显了对高危个体，特别是高暴露于ACEs的女性进行早期心理干预的潜在价值。
