Peng Yuanjun, Li Jiangheng, Wei Mingxiao, Wei Jinlu, Zeng Wei, Tang Wanting, Huang Yongquan, Tao Xing, Jiang Wu, Mao Liangqin
Department of Maternity-Child Health and Family Planning Services, Nanning Maternal and Child Health Hospital, Nanning, China.
Sci Rep. 2025 Aug 5;15(1):28591. doi: 10.1038/s41598-025-11884-0.
Syphilis is a relatively common sexually transmitted disease worldwide. Its occurrence in pregnant women not only impacts their quality of life but also leads to various adverse pregnancy outcomes (APOs), including the potential for congenital syphilis. This study sought to examine adverse pregnancy outcomes in offspring among population witl syphilis infection. Multivariate logistic regression model was used to analyze the associations between maternal syphilis infection and APOs, and to explore its stability through subgroup analysis. Our study population consisted of 1624 with syphilis in Nanning, Guangxi spanning from 2016 to 2020. Among these women, 1426 (87.81%) did not experience APOs, whereas 198 (12.19%) did. The mean age of the participants was 31.46 ± 6.08 years, with most women being first married, accounting for 77.03%. Notably, 53.08% women were belonged to the Zhuang ethnicity, and 39.16% were of Han nationality. 57.14% reported a prior syphilis infection, and 20.26% had a history of APOs with their children. The multivariate logistic regression analysis revealed that being under 20 years of age (OR: 1.911, 95% CI 1.077-3.392), having an unknown titer prior to delivery (OR: 1.792, 95% CI 1.194-2.688), and undergoing non-standardized treatment (OR: 1.448, 95% CI 1.064-1.971) emerged as significant risk factors. The implementation of comprehensive preventative measures including early syphilis screening, eugenics assessment and standardized treatment and follow-up care for pregnant women with syphilis, is of great significance in reducing the incidence of APOs in this population.
梅毒是一种在全球范围内相对常见的性传播疾病。它在孕妇中的发生不仅影响她们的生活质量，还会导致各种不良妊娠结局（APO），包括先天性梅毒的可能性。本研究旨在调查梅毒感染人群后代的不良妊娠结局。采用多因素logistic回归模型分析孕产妇梅毒感染与不良妊娠结局之间的关联，并通过亚组分析探讨其稳定性。我们的研究人群包括2016年至2020年期间广西南宁的1624例梅毒患者。在这些女性中，1426例（87.81%）未出现不良妊娠结局，而198例（12.19%）出现了不良妊娠结局。参与者的平均年龄为31.46±6.08岁，大多数女性为初婚，占77.03%。值得注意的是，53.08%的女性为壮族，39.16%为汉族。57.14%的女性报告曾感染过梅毒，20.26%的女性有过子女不良妊娠结局的病史。多因素logistic回归分析显示，年龄在20岁以下（OR：1.911，95%CI 1.077 - 3.392）、分娩前滴度不明（OR：1.792，95%CI 1.194 - 2.688）以及接受非标准化治疗（OR：1.448，95%CI 1.064 - 1.971）是显著的危险因素。实施包括早期梅毒筛查、优生评估以及对梅毒孕妇进行标准化治疗和随访护理在内的综合预防措施对于降低该人群不良妊娠结局的发生率具有重要意义。
