Bäcker Sara, Sedlmayr Brita, Goldammer Miriam, Schuler Katharina, Zerlik Maria, Strantz Cosima, Unberath Philipp, Gräßel Linda, Sedlmayr Martin, Wolfien Markus
Institute for Medical Informatics and Biometry, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.
Medical Informatics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
NPJ Precis Oncol. 2025 Aug 5;9(1):273. doi: 10.1038/s41698-025-01061-x.
Integrating Patient-Reported Outcome Measures (PROMs) into Molecular Tumor Boards (MTBs) remains challenging due to the complexity of data visualization and integration into clinical workflows. This work, as part of the German PM4Onco project, aims to identify visualization requirements for PROMs and develop a prototype for PROMs integration in cBioPortal, facilitating broader application within oncology care. We employed a qualitative research approach, including developing personas for MTB stakeholders, conducting a literature-based requirements analysis, organizing a co-design workshop to create low-fidelity prototypes, and evaluating the highest-rated prototype variant through an online survey distributed to MTB physicians across Germany. Seven specialist groups were identified, with key needs including intuitive visualization, clear axis labeling, and longitudinal symptom tracking. The resulting mid-fidelity mockup incorporated PROMs data within cBioPortal's timeline view and a detailed PROMs tab, featuring trend indicators, line graphs, and customizable health displays. Usability evaluation by MTB members yielded a SUS score of 67, indicating an initial indicator of acceptable usability, with suggestions for improvements like threshold scores and deeper clinical data integration. While PROMs offer critical patient insights, they remain underused in MTBs. Our early-stage prototype demonstrates potential for addressing this gap, with future work focusing on implementation, broader testing, and international validation.
由于数据可视化以及将其整合到临床工作流程的复杂性，将患者报告的结局指标（PROMs）整合到分子肿瘤委员会（MTBs）中仍然具有挑战性。作为德国PM4Onco项目的一部分，这项工作旨在确定PROMs的可视化要求，并开发一个在cBioPortal中整合PROMs的原型，以促进其在肿瘤护理中的更广泛应用。我们采用了定性研究方法，包括为MTB利益相关者创建人物角色、基于文献进行需求分析、组织共同设计研讨会以创建低保真原型，以及通过向德国各地的MTB医生分发在线调查问卷来评估评分最高的原型变体。确定了七个专业群体，其关键需求包括直观的可视化、清晰的轴标签和纵向症状跟踪。最终的中保真模型在cBioPortal的时间轴视图和详细的PROMs标签中纳入了PROMs数据，具有趋势指标、折线图和可定制的健康显示。MTB成员进行的可用性评估得出的系统可用性量表（SUS）评分为67，表明可用性初步可接受，并提出了如阈值分数和更深入的临床数据整合等改进建议。虽然PROMs提供了关键的患者见解，但它们在MTBs中仍未得到充分利用。我们的早期原型展示了解决这一差距的潜力，未来的工作将集中在实施、更广泛的测试和国际验证上。
