Yang Haiyan, He Liuying, Zhao Xiao, Zeng Ziqin, She Xiao, Yang Nan, Wang Qian, Zhao Ping
Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Department of Health Management, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
BMC Infect Dis. 2025 Aug 5;25(1):982. doi: 10.1186/s12879-025-11394-4.
Circadian syndrome (CircS) provides a more comprehensive reflection of metabolic health than metabolic syndrome (MetS), yet studies exploring its association with H.pylori infection are still limited. The study aimed to examine the association between CircS and its components, as well as H.pylori infection, among individuals undergoing routine health screenings.
We collected data from health examination population who underwent a ¹³C-urea breath test (¹³C-UBT) at a tertiary hospital in Northwest China from July 1, 2021, to June 30, 2023, for a cross-sectional study. The study population was divided into H. pylori-positive and H. pylori-negative groups based on H.pylori infection status, and a binary logistic regression model was constructed to analyze the relationship between H.pylori infection and CircS and its components.
The study included 29,621 individuals, after adjusting for covariates, H.pylori infection showed a significant association with the prevalence of CircS (OR 1.17, 95% CI 1.08,1.27, P < 0.001), with the association being modified by smoking. Additionally, some of the components of CircS were associated with an increased risk of H.pylori infection, including central obesity, lowered high-density lipoprotein-cholesterol (HDL-C), elevated blood pressure (BP), and short sleep (OR 1.12, 95% CI 1.06,1.19; OR 1.14,95% CI 1.08,1.20; OR 1.10,95% CI 1.04,1.17; OR 1.11, 95% CI 1.02,1.20). No significant association was found between depression, elevated fasting blood glucose (FBG) and elevated triglycerides (TG) and H.pylori infection.
This study identifies CircS as an independent risk factor for H.pylori infection, that smoking appears to modify this relationship, and that some of the CircS components are significantly and positively associated with H.pylori infection.
昼夜节律综合征（CircS）比代谢综合征（MetS）能更全面地反映代谢健康状况，但探索其与幽门螺杆菌感染关联的研究仍然有限。本研究旨在调查接受常规健康筛查的个体中CircS及其组成成分与幽门螺杆菌感染之间的关联。
我们收集了2021年7月1日至2023年6月30日在中国西北部一家三级医院接受¹³C尿素呼气试验（¹³C-UBT）的健康体检人群的数据，进行横断面研究。根据幽门螺杆菌感染状况将研究人群分为幽门螺杆菌阳性组和幽门螺杆菌阴性组，并构建二元逻辑回归模型分析幽门螺杆菌感染与CircS及其组成成分之间的关系。
该研究纳入了29,621名个体，在对协变量进行调整后，幽门螺杆菌感染与CircS的患病率显著相关（OR 1.17，95%CI 1.08,1.27，P < 0.001），且这种关联受吸烟影响。此外，CircS的一些组成成分与幽门螺杆菌感染风险增加相关，包括中心性肥胖、高密度脂蛋白胆固醇（HDL-C）降低、血压升高和睡眠不足（OR 1.12，95%CI 1.06,1.19；OR 1.14，95%CI 1.08,1.20；OR 1.10，95%CI 1.04,1.17；OR 1.11，95%CI 1.02,1.20）。未发现抑郁、空腹血糖（FBG）升高和甘油三酯（TG）升高与幽门螺杆菌感染之间存在显著关联。
本研究确定CircS是幽门螺杆菌感染的独立危险因素，吸烟似乎会改变这种关系，且CircS的一些组成成分与幽门螺杆菌感染存在显著正相关。
