Department of Gastroenterology, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, 317000, Zhejiang, China.
Health Management Center, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, 317000, Zhejiang, China.
BMC Infect Dis. 2024 Jul 25;24(1):730. doi: 10.1186/s12879-024-09597-2.
In contemporary times, increased prevalence of Helicobacter pylori (H. pylori) infection and elevated dyslipidemia levels present substantial public health challenges. However, the relationship between H. pylori and dyslipidemia remains inconclusive. No studies have yet conducted a population-based classification to investigate the impact of H. pylori infection on dyslipidemia in individuals with diabetes.
A retrospective cohort study was carried out on a total of 60,535 individuals who underwent health check-ups at the Health Examination Center in Taizhou Hospital from 2017 to 2022. Physical measurements, hematological markers and detection of H. pylori were gathered from all patients. The study population was further stratified into diabetic and non-diabetic groups for analysis.
H. pylori infection was found to be an autonomous risk factor for dyslipidemia based on the results of multivariate logistic regression analysis (OR = 1.13, 95% CI: 1.03-1.24). However, no notable effect on dyslipidemia in the non-diabetic group was observed. Furthermore, at the follow-up, the group with persistent negative showed a significantly lower incidence ratio of dyslipidemia compared to the group with persistent infection (P = 0.006). The persistent negative group exhibited a significantly higher rate of improvement in dyslipidemia compared to the new infection group (P = 0.038).
In the diabetic population, the presence of H. pylori infection heightens the propensity for developing dyslipidemia. Therefore, the implementation of efficient eradication strategies for H. pylori infection could potentially lead to a decrease in the occurrence of dyslipidemia among individuals with diabetes.
在当代，幽门螺杆菌（H. pylori）感染的流行率增加和血脂水平升高对公共健康构成了重大挑战。然而，H. pylori 与血脂异常之间的关系仍不确定。目前尚无研究采用基于人群的分类方法来调查 H. pylori 感染对糖尿病患者血脂异常的影响。
本研究采用回顾性队列研究，共纳入 2017 年至 2022 年在台州医院健康检查中心接受健康检查的 60535 例个体。收集所有患者的体格测量、血液标志物和 H. pylori 检测结果。根据是否患有糖尿病，将研究人群进一步分为糖尿病组和非糖尿病组进行分析。
多变量逻辑回归分析结果显示，H. pylori 感染是血脂异常的独立危险因素（OR=1.13，95%CI：1.03-1.24）。然而，在非糖尿病组中，H. pylori 感染对血脂异常没有显著影响。此外，在随访中，持续阴性组的血脂异常发生率明显低于持续感染组（P=0.006）。与新发感染组相比，持续阴性组的血脂异常改善率明显更高（P=0.038）。
在糖尿病患者中，H. pylori 感染的存在增加了发生血脂异常的倾向。因此，实施有效的 H. pylori 感染根除策略可能会降低糖尿病患者血脂异常的发生。
