Mathys C, De Dobbeleer G, Ledoux M, Achten G
Dermatologica. 1985;171(4):283-90.
The authors show the noteworthy efficacy of the aromatic retinoid Ro 10-9359 in the treatment of ichthyosis linearis circumflexa. The initial dose was 1 mg/kg daily; later on, the maintenance dose was 0.3 mg/kg daily. Ultrastructurally, transitional cells were observed between the granular and the horny layer. After treatment, large perinuclear pseudovacuoles appeared, as well as numerous microvilli.
作者展示了芳香维甲酸Ro 10-9359治疗线状回旋性鱼鳞病的显著疗效。初始剂量为每日1毫克/千克；之后，维持剂量为每日0.3毫克/千克。超微结构观察显示，颗粒层和角质层之间出现了过渡细胞。治疗后，出现了大的核周假空泡以及大量微绒毛。
