Allison Grant, Gauger Phillip, Osemeke Onyekachukwu, Lawrence Paul
Walcott Veterinary Clinic, Walcott, IA, United States.
Veterinary Diagnostic Laboratory, Department of Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames, IA, United States.
Front Vet Sci. 2025 Jul 22;12:1598231. doi: 10.3389/fvets.2025.1598231. eCollection 2025.
Despite more than three decades of research and improved biosecurity, porcine reproductive and respiratory syndrome virus (PRRSV) still causes major economic losses to the swine industry. The continued losses, especially in growing-pig populations, prompt exploration of adjunct therapies. This longitudinal field study evaluated whether orally delivered Ivermectin (0.3 mg/kg in four two-day pulses) mitigates PRRSV in a 2,400 wean-to-market barn. Treated pens recorded numerically fewer PRRSV-positive pens during the first 17 days post-weaning, as determined by oral-fluid (OF) RT-qPCR, and lower mean log₁₀ viral copies in OF at eight of nine weekly samplings across 68 days. Serum RT-qPCR, however, revealed numerically higher viremia in treated pigs. These findings warrant further studies using better trial settings or different dosing strategies.
尽管经过了三十多年的研究以及生物安全措施的改进，猪繁殖与呼吸综合征病毒（PRRSV）仍然给养猪业造成重大经济损失。持续的损失，尤其是在生长猪群中，促使人们探索辅助治疗方法。这项纵向田间研究评估了口服伊维菌素（以四个为期两天的脉冲形式给药，剂量为0.3毫克/千克）是否能在一个有2400头仔猪至上市猪的猪舍中减轻PRRSV感染。通过口服液体（OF）逆转录定量聚合酶链反应（RT-qPCR）测定，在断奶后的前17天，接受治疗的猪栏中PRRSV阳性猪栏的数量在数值上较少，并且在68天内的九个每周采样中有八个采样时，OF中的平均log₁₀病毒拷贝数较低。然而，血清RT-qPCR显示，接受治疗的猪的病毒血症在数值上更高。这些发现需要使用更好的试验设置或不同的给药策略进行进一步研究。
