Wan Qi, Wei Ran, Tang Jing, Deng Ying-Ping, Ma Ke
Department of Ophthalmology, West China Hospital of Sichuan University, Chengdu, People's Republic of China.
Clin Ophthalmol. 2025 Aug 1;19:2541-2548. doi: 10.2147/OPTH.S544117. eCollection 2025.
The study aimed to assess the impact of VISULYZE nomogram software on refractive outcomes after lenticule extraction for myopia and myopic astigmatism correction.
This ambispective, single-site, matched case-control study was conducted at West China Hospital in Chengdu, China. Treatments using the VISULYZE nomogram were compared to a control group without it. The main outcome was refractive accuracy at 3 months, measured by the proportion of eyes achieving a spherical equivalent (SEQ) within ±0.50 D of the target and astigmatism ≤0.50 D.
The study involved 180 eyes, with 90 treated using VISULYZE and 90 matched controls analyzed retrospectively. In the VISULYZE group, 98.9% achieved SEQ within ±0.50 D versus 85.6% in the control group (P<0.001). Astigmatism ≤0.50 D was achieved in 100% of VISULYZE-treated eyes compared to 93.3% in controls (P=0.006). Both groups had similar safety indices. VISULYZE showed higher correlations between attempted and achieved SEQ (R²=0.9799) and astigmatism (R²=0.8996) compared to the control group (SEQ: R²=0.9590; Astig: R²=0.5992). Standard efficacy and safety measures showed no difference between groups.
The VISULYZE-generated nomogram demonstrated improved predictability and accuracy in refractive outcomes. It may enhance results for surgeons compared to those using no nomogram or a standard offset nomogram.
本研究旨在评估VISULYZE列线图软件对近视和近视散光矫正的晶状体透镜摘除术后屈光结果的影响。
本双盲、单中心、匹配病例对照研究在中国成都的华西医院进行。将使用VISULYZE列线图的治疗与未使用该软件的对照组进行比较。主要结果是术后3个月的屈光精度，通过达到目标球镜等效度数（SEQ）±0.50 D以内且散光≤0.50 D的眼睛比例来衡量。
该研究共纳入180只眼，其中90只使用VISULYZE进行治疗，另外90只作为匹配对照进行回顾性分析。在VISULYZE组中，98.9%的眼睛达到了SEQ±0.50 D以内，而对照组为85.6%（P<0.001）。VISULYZE治疗的眼睛中有100%达到了散光≤0.50 D，而对照组为93.3%（P=0.006）。两组的安全指标相似。与对照组相比，VISULYZE在预期SEQ和实际SEQ之间（R²=0.9799）以及散光之间（R²=0.8996）显示出更高的相关性（对照组SEQ：R²=0.9590；散光：R²=0.5992）。标准疗效和安全指标在两组之间无差异。
VISULYZE生成的列线图在屈光结果方面显示出更高的可预测性和准确性。与不使用列线图或使用标准偏移列线图的外科医生相比，它可能会改善手术效果。
