McHardy N
Tropenmed Parasitol. 1977 Jun;28(2):195-201.
Groups of 10 mice were infected by the s.c. injection of blood trypomastigotes of Trypanosoma cruzi, strains "Y" and "Tulahuen". They were injected i.p. with convalescent mouse-anti-T. cruzi serum (CMATS) at various times. A single dose of CMATS (Y) was most effective when injected one day after homologous infection -31 of 40 mice survived the infection, whereas all controls, both untreated and injected with normal serum, died. CMATS was significantly less effective in treating mice infected with the Tulahuen strain. Sera from animals immunized with killed epimastigotes or trypomastigotes showed only very slight passive immunizing properties.
将10只小鼠分为一组，通过皮下注射克氏锥虫“Y”株和“图拉温”株的血液型锥鞭毛体进行感染。在不同时间给它们腹腔注射恢复期小鼠抗克氏锥虫血清（CMATS）。同源感染后一天注射单剂量的CMATS（Y）最为有效——40只小鼠中有31只在感染后存活，而所有未治疗和注射正常血清的对照组小鼠均死亡。CMATS在治疗感染图拉温株的小鼠时效果明显较差。用灭活的上鞭毛体或锥鞭毛体免疫的动物血清仅表现出非常轻微的被动免疫特性。
