胸腺依赖性对宿主抗克氏锥虫感染防御机制的控制。
Thymus-dependent control of host defense mechanisms against Trypanosoma cruzi infection.
作者信息
Kierszenbaum F, Pienkowski M M
出版信息
Infect Immun. 1979 Apr;24(1):117-20. doi: 10.1128/iai.24.1.117-120.1979.
Abstract
Congenitally athymic homozygous (nu/nu) mice were shown to be significantly more susceptible to Trypanosoma cruzi infection than their thymus-bearing heterozygous (nu/+) littermates, as measured by increased parasitemia, mortality rate, and shortened survival time. In addition, transplantation of neonatal thymus into athymic mice reestablished normal levels of resistance to T. cruzi, i.e., comparable to those of normal littermates. These results constitute conclusive evidence that host defense mechanisms active in experimental Chagas' disease are under thymic control.
摘要
先天性无胸腺纯合子（nu/nu）小鼠比其有胸腺的杂合子（nu/+）同窝小鼠对克氏锥虫感染的易感性显著更高，这通过寄生虫血症增加、死亡率和生存时间缩短来衡量。此外，将新生胸腺移植到无胸腺小鼠中可重建对克氏锥虫的正常抵抗水平，即与正常同窝小鼠相当。这些结果构成了确凿的证据，表明在实验性恰加斯病中起作用的宿主防御机制受胸腺控制。
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