Cuschieri R J, Morran C G, Lowe G D, Blamey S L, Forbes C D, McArdle C S
Haemostasis. 1985;15(5):353-6. doi: 10.1159/000215171.
Platelet aggregation in the lungs is common following abdominal surgery and may contribute to postoperative hypoxaemia. The hypothesis that an anabolic steroid, stanozolol, by preventing fibrinolytic shutdown, would prevent postoperative hypoxaemia was tested. Fifty patients undergoing abdominal surgery were randomly allocated to receive either placebo or stanozolol. Despite preventing fibrinolytic shutdown in most patients, the use of stanozolol did not influence the extent of postoperative hypoxaemia or the incidence of postoperative pulmonary complications. These results suggest that fibrinolysis does not play a significant part in the pathogenesis of postoperative pulmonary dysfunction.
腹部手术后肺部血小板聚集很常见，可能导致术后低氧血症。我们对一种合成代谢类固醇——司坦唑醇能否通过防止纤维蛋白溶解停止来预防术后低氧血症这一假说进行了验证。50例接受腹部手术的患者被随机分配接受安慰剂或司坦唑醇。尽管在大多数患者中防止了纤维蛋白溶解停止，但司坦唑醇的使用并未影响术后低氧血症的程度或术后肺部并发症的发生率。这些结果表明，纤维蛋白溶解在术后肺功能障碍的发病机制中并不起重要作用。
