Brenner P, Wannske M
Handchir Mikrochir Plast Chir. 1985 Nov;17 Suppl:56-9.
Melorheostosis is a rare sclerosing bone dysplasia affecting children and adults. Concerning the etiology it seems to be a metameric abnormality of the tissue of mesodermal origin, which is initiated early in embryonic life prior to the formation of the extremity buds. The flowing hyperostosis is usually associated with limb deformity, soft tissue contractures, severe pain and stiffness of joints. Bone scanning complements standard radiologic studies and permits evaluation of the extent and activity of the disease. Conservative treatment is disappointing. Thus we recommend the excision of the exostoses at an early state to prevent further deformity as is shown in a clinical case report.
肢骨纹状肥大是一种罕见的硬化性骨发育异常，可累及儿童和成人。关于其病因，似乎是中胚层起源组织的节段性异常，这种异常在胚胎早期肢体芽形成之前就已开始。流动的骨质增生通常与肢体畸形、软组织挛缩、关节严重疼痛和僵硬有关。骨扫描补充了标准的放射学检查，并有助于评估疾病的范围和活动情况。保守治疗效果不佳。因此，正如一份临床病例报告所示，我们建议在早期切除骨疣以防止进一步畸形。
