胶原蛋白糖基化中的酶促工艺
Enzymatic craftsmanship in collagen glycosylation.
作者信息
Ghosh Susovon, Kumar Dilip, Mondal Bhaskar, Basak Trayambak
机构信息
School of Chemical Sciences, Indian Institute of Technology (IIT) Mandi, Mandi, Himachal Pradesh, India.
Trivedi School of Biosciences, Ashoka University, Haryana, India.
出版信息
Nat Commun. 2025 Aug 6;16(1):7252. doi: 10.1038/s41467-025-62768-w.
Collagen IV, a key structural protein of basement membranes, is vital for the development and survival of multicellular life forms. Its maturation relies on specific post-translational O- glycosylation, primarily mediated by lysyl hydroxylase-3 (LH3) and other glycosyltransferases, which sculpt collagen by modifying the hydroxylysine residues with sugar moieties.
IV型胶原蛋白是基底膜的一种关键结构蛋白，对多细胞生命形式的发育和存活至关重要。其成熟依赖于特定的翻译后O-糖基化，主要由赖氨酰羟化酶-3（LH3）和其他糖基转移酶介导，这些酶通过用糖基修饰羟赖氨酸残基来塑造胶原蛋白。
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