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通过静脉输注乙酰半胱氨酸治疗大量摄入四氯化碳后的存活率。

Survival after massive ingestion of carbon tetrachloride treated by intravenous infusion of acetylcysteine.

作者信息

Mathieson P W, Williams G, MacSweeney J E

出版信息

Hum Toxicol. 1985 Nov;4(6):627-31. doi: 10.1177/096032718500400610.

DOI:10.1177/096032718500400610
PMID:4077074
Abstract

A 61-year-old man ingested a large amount of carbon tetrachloride, well in excess of the adult lethal dose. The level of the compound was assayed in his blood and the levels were the highest ever recorded by the Guy's Hospital Poisons Unit. He was treated by intravenous infusion of acetylcysteine and survived with relatively mild clinical and biochemical evidence of toxicity. Possible reasons for his survival are discussed, as are the implications for the management of future cases.

摘要

一名61岁男子摄入了大量四氯化碳,远超成人致死剂量。对其血液中的该化合物水平进行了检测,检测结果是盖伊医院中毒科所记录的最高水平。他接受了静脉注射乙酰半胱氨酸治疗,存活下来,仅有相对较轻的临床和生化毒性证据。文中讨论了他存活的可能原因以及对未来病例管理的启示。

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Survival after massive ingestion of carbon tetrachloride treated by intravenous infusion of acetylcysteine.通过静脉输注乙酰半胱氨酸治疗大量摄入四氯化碳后的存活率。
Hum Toxicol. 1985 Nov;4(6):627-31. doi: 10.1177/096032718500400610.
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Acute chloroform ingestion successfully treated with intravenously administered N-acetylcysteine.静脉注射N-乙酰半胱氨酸成功治疗急性氯仿摄入。
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Reversibility of liver damage in rats rendered resistant to carbon tetrachloride by prior carbon tetrachloride administration: bearing on the lipoperoxidation hypothesis.预先给予四氯化碳使大鼠对四氯化碳产生抗性后肝脏损伤的可逆性:与脂质过氧化假说的关系
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[Use of intraportal infusion therapy in acute carbon tetrachloride poisoning in animals].[门静脉内输注疗法在动物急性四氯化碳中毒中的应用]
Gig Tr Prof Zabol. 1975 May(5):39-43.

引用本文的文献

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The biosynthesis of taurine fromN-acetyl-L-cysteine and other precursorsin vivo and in rat hepatocytes.牛磺酸的生物合成来自于体内和大鼠肝细胞中的 N-乙酰-L-半胱氨酸和其他前体。
Amino Acids. 1996 Jun;10(2):173-85. doi: 10.1007/BF00806590.
2
N-acetylcysteine attenuates alcohol-induced oxidative stress in the rat.N-乙酰半胱氨酸减轻大鼠酒精诱导的氧化应激。
World J Gastroenterol. 2003 Jan;9(1):125-8. doi: 10.3748/wjg.v9.i1.125.
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Utility of acetylcysteine in treating poisonings and adverse drug reactions.乙酰半胱氨酸在治疗中毒及药物不良反应中的应用
Drug Saf. 2000 Feb;22(2):123-48. doi: 10.2165/00002018-200022020-00005.
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Diagnosis of chlorinated hydrocarbon poisoning by x ray examination.通过X线检查诊断氯代烃中毒。
Br J Ind Med. 1987 Jun;44(6):424-5. doi: 10.1136/oem.44.6.424.
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The role of acetylcysteine in clinical toxicology.乙酰半胱氨酸在临床毒理学中的作用。
Med Toxicol. 1987 Mar-Apr;2(2):93-104. doi: 10.1007/BF03260008.
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Hyperbaric oxygen treatment for carbon tetrachloride poisoning.高压氧治疗四氯化碳中毒
Drug Saf. 1991 Sep-Oct;6(5):332-8. doi: 10.2165/00002018-199106050-00003.