Li Qian, Luo Wanyi, Xiao Li, Xu Xin, Peng Xian, Cheng Lei, Zhou Xuedong, Zheng Xin
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R. China.
Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R. China.
J Oral Microbiol. 2025 Aug 5;17(1):2544169. doi: 10.1080/20002297.2025.2544169. eCollection 2025.
, a microorganism ordinarily detected in the oral cavity, is considered as a pathobiont related to periodontitis and a range of human diseases, including colorectal cancer (CRC). The dynamics of how encourages CRC tumorigenesis and progression has been well-investigated. Recently, mechanisms by which regulates the tumor immune microenvironment (TiME) and subsequently alters CRC oncogenesis and advancement have drawn more and more attention. The TiME consists of immune cells and non-cellular components like cytokines in the tumor microenvironment. By contacting immune cells in the TiME, fosters an immunosuppressive TiME, diminishes anti-tumor immunity and promotes CRC development. This also allows to interfere with immunotherapy process and efficacy. In this review, we present a summary of how interacts with immune cells within the TiME, thereby promoting CRC progression and influencing CRC immunotherapy effectiveness. This review also integrates insights from molecular pathological epidemiology (MPE) to contextualize host-microbe-environment interactions in CRC. We identify gaps in current knowledge and outline possible future research paths. These findings may offer valuable insights for future mechanistic research and the development of novel therapeutic strategies.
作为一种通常在口腔中检测到的微生物，被认为是与牙周炎及一系列人类疾病（包括结直肠癌，CRC）相关的病理共生菌。关于其如何促进CRC肿瘤发生和进展的动态过程已得到充分研究。最近，其调节肿瘤免疫微环境（TiME）并随后改变CRC发生和进展的机制越来越受到关注。TiME由肿瘤微环境中的免疫细胞和细胞因子等非细胞成分组成。通过与TiME中的免疫细胞接触，其促进免疫抑制性TiME的形成，削弱抗肿瘤免疫力并促进CRC发展。这也使得其能够干扰免疫治疗过程和疗效。在本综述中，我们总结了其如何与TiME内的免疫细胞相互作用，从而促进CRC进展并影响CRC免疫治疗效果。本综述还整合了分子病理流行病学（MPE）的见解，以将CRC中的宿主-微生物-环境相互作用置于背景中。我们确定了当前知识中的差距并概述了未来可能的研究路径。这些发现可能为未来的机制研究和新型治疗策略的开发提供有价值的见解。
