Wu Weidong, Meng Tianwei, Jin Fangfang, Li Junwei, Huang Jiahao, Guo Zhuang, Yu Miao, Zhou Yanyan
Key Laboratory of Basic Theory of Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin, China.
Department of Internal Medicine, Heilongjiang University of Chinese Medicine, Harbin, China.
Front Pharmacol. 2025 Jul 23;16:1588284. doi: 10.3389/fphar.2025.1588284. eCollection 2025.
This meta-analysis aims to systematically evaluate the impact of resveratrol on postmenopausal women.
We searched seven electronic databases and conducted meta-analyses using Stata 12.0.
Ten randomized controlled trials (RCTs) with 928 participants were identified. Resveratrol significantly reduced pain scores (WMD: -2.841, 95% CI: -5.631 to -0.050, p = 0.046), pain VAS scores (WMD: -7.585, 95% CI: -12.912 to -2.257, p = 0.005), PPI scores (WMD: -8.563, 95% CI: -12.866 to -4.261, p < 0.001), and CTX levels (WMD: -0.137, 95% CI: -0.204 to -0.070, p < 0.001). However, no significant effects were observed on cognition and memory (e.g., PVT, ORR, PSM, RAVLT, LSWM, FSS, DCCS, FICA, TMT), mood (depression, overall mood), metabolic parameters (glucose, insulin, HOMA-IR, triglycerides, total cholesterol, LDL-C, HDL-C), blood pressure, sleep disturbance, menopausal symptoms, SF-36 quality of life, or bone markers ALP and OC.
Resveratrol may improve pain and bone metabolism (CTX) in postmenopausal women but did not affect other examined outcomes. Future large-scale trials are needed to confirm these findings and determine optimal dosing and treatment strategies.
https://www.crd.york.ac.uk/PROSPERO/#myprospero, identifier CRD42024566807.
本荟萃分析旨在系统评估白藜芦醇对绝经后女性的影响。
我们检索了七个电子数据库，并使用Stata 12.0进行荟萃分析。
共纳入10项随机对照试验（RCT），涉及928名参与者。白藜芦醇显著降低了疼痛评分（加权均数差：-2.841，95%置信区间：-5.631至-0.050，p = 0.046）、疼痛视觉模拟评分（加权均数差：-7.585，95%置信区间：-12.912至-2.257，p = 0.005）、疼痛概率指数评分（加权均数差：-8.563，95%置信区间：-12.866至-4.261，p < 0.001）和Ⅰ型胶原交联C末端肽（CTX）水平（加权均数差：-0.137，95%置信区间：-0.204至-0.070，p < 0.001）。然而，在认知和记忆（如选择反应时、物体识别率、语义记忆、雷伊听觉词语学习测验、逻辑记忆广度、疲劳严重程度量表、数字划消测验、面部识别能力、连线测验）、情绪（抑郁、总体情绪）、代谢参数（血糖、胰岛素、稳态模型评估胰岛素抵抗指数、甘油三酯、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇）、血压、睡眠障碍、绝经症状、SF-36生活质量或骨标志物碱性磷酸酶（ALP）和骨钙素（OC）方面未观察到显著影响。
白藜芦醇可能改善绝经后女性的疼痛和骨代谢（CTX），但不影响其他所检测的结果。未来需要大规模试验来证实这些发现，并确定最佳剂量和治疗策略。
https://www.crd.york.ac.uk/PROSPERO/#myprospero，标识符CRD42024566807。
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