Di Stadio Arianna, Messineo Daniela, Indovina Iole, Motta Giovanni, Ralli Massimo, Brenner Michael J
Department of Otolaryngology, University of Campania "Luigi Vanvitelli", Naples, Italy.
Dipartimento di Scienze Radiologiche, Oncologiche ed Anatomo Patologiche, University La Sapienza, Rome, Italy.
Front Neurol. 2025 Jul 23;16:1558196. doi: 10.3389/fneur.2025.1558196. eCollection 2025.
Vascular anomalies are commonly associated with pulsatile tinnitus, but their potential role in triggering non-pulsatile tinnitus through neuroinflammation is not well established. Furthermore, few studies have investigated non-pulsatile tinnitus associated with altered cerebrovascular supply and whether anti-neuroinflammatory therapy might alleviate symptoms.
We describe two patients presenting with non-pulsatile tinnitus and sigmoid sinus stenosis confirmed by imaging, with other causes systematically excluded.
Magnetic resonance venography demonstrated severe stenosis of the transverse and sigmoid sinuses, alongside compensatory ipsilateral vascular dilatation. These structural abnormalities suggested disrupted venous blood flow, contributing to the neuroinflammatory processes associated with non-pulsatile tinnitus. Following treatment with an anti-inflammatory molecule, both patients reported a substantial reduction in tinnitus severity.
This study supports the potential of anti-inflammatory treatments in managing non-pulsatile tinnitus linked to sinus vascular anomalies. Further research is warranted to elucidate these relationships and confirm therapeutic efficacy of anti-inflammatory agents.
血管异常通常与搏动性耳鸣相关，但其通过神经炎症触发非搏动性耳鸣的潜在作用尚未明确。此外，很少有研究调查与脑血管供应改变相关的非搏动性耳鸣，以及抗神经炎症治疗是否可能缓解症状。
我们描述了两名经影像学证实患有非搏动性耳鸣和乙状窦狭窄的患者，同时系统排除了其他病因。
磁共振静脉血管造影显示横窦和乙状窦严重狭窄，同时同侧血管出现代偿性扩张。这些结构异常提示静脉血流中断，导致与非搏动性耳鸣相关的神经炎症过程。在使用抗炎分子治疗后，两名患者均报告耳鸣严重程度大幅降低。
本研究支持抗炎治疗在管理与鼻窦血管异常相关的非搏动性耳鸣方面的潜力。有必要进一步研究以阐明这些关系并确认抗炎药物的治疗效果。
