Naik Sonali S, Dutta Naba K, Choudhury Namita Roy
Polymer Science and Engineering, CSIR-National Chemical Laboratory, Pune, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India; School of Engineering, RMIT University, Melbourne, VIC 3000, Australia.
School of Engineering, RMIT University, Melbourne, VIC 3000, Australia.
Adv Colloid Interface Sci. 2025 Nov;345:103604. doi: 10.1016/j.cis.2025.103604. Epub 2025 Jul 18.
The trachea is a vital respiratory organ that connects the larynx to the lungs and performs crucial functions. Various conditions can cause severe and often irreversible damage to individuals trachea of all age groups. Tracheal regeneration remains a major challenge in respiratory medicine, requiring a innovative solutions to address various underlying causes. Existing clinical interventions often have significant limitations and associated complications. Tissue engineering has potential, but its effectiveness has been limited due to challenges such as poor durability and insufficient revascularization. This review aims to provide a comprehensive exploration of the landscape of tracheal regeneration, shedding light on the path towards advancements in addressing extensive tracheal defects. It follows a structured approach, introducing various surgical procedures, along with their associated complications. Subsequently, it delves into the myriad biomaterials investigated in the realm of tracheal tissue engineering, emphasizing the significance of design considerations in scaffold fabrication. The review then navigates through various platforms utilized in tracheal tissue engineering and recent innovative approaches employed in this domain. Additionally, it provides insights into the clinical translation of tissue-engineered trachea, highlighting recent advancements and challenges encountered in real-world applications. Finally, it discusses the significant challenges and offers a perspective outlook on the future of tracheal tissue engineering. Addressing current limitations and envisioning novel strategies, the review contributes to the ongoing dialogue and progression in this critical field of regenerative medicine.
气管是一个重要的呼吸器官，它连接喉与肺并执行关键功能。各种情况可对所有年龄组的个体气管造成严重且往往不可逆转的损害。气管再生仍然是呼吸医学中的一项重大挑战，需要创新的解决方案来应对各种潜在原因。现有的临床干预措施往往有显著局限性及相关并发症。组织工程有潜力，但其有效性因耐久性差和血管再生不足等挑战而受到限制。本综述旨在全面探索气管再生的情况，阐明解决广泛气管缺损方面取得进展的途径。它采用结构化方法，介绍各种手术程序及其相关并发症。随后，深入探讨气管组织工程领域研究的众多生物材料，强调支架制造中设计考虑因素的重要性。该综述接着介绍气管组织工程中使用的各种平台以及该领域最近采用的创新方法。此外，它还深入探讨了组织工程气管的临床转化，突出了实际应用中最近取得的进展和遇到的挑战。最后，讨论了重大挑战，并对气管组织工程的未来提供了前瞻性展望。本综述通过解决当前的局限性并设想新策略，为再生医学这一关键领域正在进行的对话和进展做出了贡献。
