儿童肺炎衣原体肺炎（CPP）与肺炎支原体肺炎的对比分析及重症CPP的危险因素

Comparative analysis of Chlamydia pneumoniae pneumonia (CPP) and Mycoplasma pneumoniae pneumonia in children and risk factors of severe CPP.

作者信息

Huang Yu, Chen Yi, Liu Min, Tang Lan-Fang, Tang Lan-Fang

机构信息

Department of Pulmonology, School of Medicine, Children's Hospital of Zhejiang University, National Clinical Research Center for Child Health, No 3333, Binsheng Rd, Hangzhou, Hangzhou, 310052, Zhejiang, China.

出版信息

BMC Infect Dis. 2025 Aug 7;25(1):993. doi: 10.1186/s12879-025-11405-4.

DOI:10.1186/s12879-025-11405-4

PMID:40775274

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12329983/

Abstract

BACKGROUND

Chlamydia penumoniae (CP) pneumonia (CPP) in children often receives less clinical attention due to its relatively mild presentation. This study comparatively analyzed CPP and Mycoplasma pneumoniae pneumonia (MPP), and investigated risk factors for severe CPP.

METHODS

A retrospective analysis was conducted on 176 CPP patients and 176 concurrently hospitalized MPP patients during the same period to compare clinical features. CPP cases were further stratified into severe and mild subgroup to identify risk factors.

RESULTS

The number of hospitalized children with CPP increased in 2024 compared to 2023, with a significant surge observed from December 2024 to February 2025. CPP patients were significantly older than MPP patients (mean age: 10.53 ± 2.89 vs. 6.68 ± 2.88, p < 0.05) and exhibited longer durations of cough and higher rates of chest pain (p < 0.05). Laboratory findings revealed significantly elevated white blood cell (WBC) and eosinophil (EOS) counts in CPP versus MPP (p < 0.05). Severe CPP accounted for 6.8% of cases, and binary logistic regression identified eosinophil count as a potential biomarker for severe CPP (p < 0.05).

CONCLUSIONS

The number of hospitalized children with CPP increased in 2024 compared to 2023. CPP manifested more prominent cough and chest pain symptoms compared to MPP patients. EOS count levels may serve as a potential biomarker of severe CPP.

摘要

背景

儿童肺炎衣原体（CP）肺炎（CPP）因其临床表现相对较轻，常较少受到临床关注。本研究对CPP和肺炎支原体肺炎（MPP）进行了比较分析，并调查了重症CPP的危险因素。

方法

对176例CPP患者和同期176例住院的MPP患者进行回顾性分析，以比较临床特征。将CPP病例进一步分为重症和轻症亚组，以确定危险因素。

结果

与2023年相比，2024年住院的CPP患儿数量增加，2024年12月至2025年2月出现显著激增。CPP患者明显比MPP患者年龄大（平均年龄：10.53±2.89岁 vs. 6.68±2.88岁，p<0.05），咳嗽持续时间更长，胸痛发生率更高（p<0.05）。实验室检查结果显示，与MPP相比，CPP患者的白细胞（WBC）和嗜酸性粒细胞（EOS）计数显著升高（p<0.05）。重症CPP占病例的6.8%，二元逻辑回归确定嗜酸性粒细胞计数为重症CPP的潜在生物标志物（p<0.05）。