Ax Anna-Karin, Stenling Andreas, Berntsen Sveinung, Börjeson Sussanne, Nordin Karin, Demmelmaier Ingrid, Mazzoni Anne-Sophie
Uppsala University, Sweden.
Linköping University, Sweden.
Integr Cancer Ther. 2025 Jan-Dec;24:15347354251362447. doi: 10.1177/15347354251362447. Epub 2025 Aug 8.
Regular physical activity improves health outcomes in cancer survivors; however, maintaining recommended levels of moderate-to-vigorous intensity physical activity (MVPA) post-treatment is challenging, even for those participating in exercise intervention studies. Understanding long-term MVPA patterns and predictors can guide strategies to promote sustained physical activity in this population. We aimed to describe objectively measured MVPA-profiles over 5 years in cancer survivors who participated in a 6-month exercise intervention during cancer treatment, and to identify baseline predictors of profile belonging.
Data were derived from the multicenter randomized controlled trial Phys-Can, including participants with breast, colorectal or prostate cancer. Objective measures of MVPA were conducted at baseline, post-intervention, and at 1-, 2-, and 5-year follow-ups. Longitudinal latent profile analysis was used to identify MVPA profiles, and multinomial logistic regression to examine potential baseline predictors of profile belonging.
Among 556 participants, 4 longitudinal MVPA profiles were identified: (18.0%), Medium (40.8%), (28.4%), and (12.8%). Compared to the MVPA profile, participants in the MVPA profile were more likely to be women (OR = 20.64) or have higher BMI (OR = 1.41) or lower cardiorespiratory fitness (OR = 0.69) at baseline.
Cancer survivors who are women or have a higher BMI and/or low cardiorespiratory fitness prior to cancer treatment are at greater risk of maintaining low MVPA levels over time. These groups may require targeted support to enhance and sustain physical activity during survivorship.
规律的体育活动可改善癌症幸存者的健康状况；然而，即使对于参与运动干预研究的人来说，在治疗后维持推荐水平的中等至剧烈强度体育活动（MVPA）也具有挑战性。了解长期的MVPA模式和预测因素可以指导促进该人群持续体育活动的策略。我们旨在描述在癌症治疗期间参加了为期6个月运动干预的癌症幸存者5年期间客观测量的MVPA概况，并确定概况归属的基线预测因素。
数据来自多中心随机对照试验Phys-Can，包括乳腺癌、结直肠癌或前列腺癌患者。在基线、干预后以及1年、2年和5年随访时进行MVPA的客观测量。纵向潜在概况分析用于识别MVPA概况，多项逻辑回归用于检查概况归属的潜在基线预测因素。
在556名参与者中，确定了4种纵向MVPA概况：[概况1（18.0%）]、中等（40.8%）、[概况3（28.4%）]和[概况4（12.8%）]。与[概况1]MVPA概况相比，[概况4]MVPA概况的参与者在基线时更有可能是女性（OR = 20.64）或BMI较高（OR = 1.41）或心肺适能较低（OR = 0.69）。
在癌症治疗前为女性或BMI较高和/或心肺适能较低的癌症幸存者，随着时间推移维持低MVPA水平的风险更大。这些群体可能需要有针对性的支持，以在康复期间加强和维持体育活动。
