Uppsala University, Uppsala, Sweden.
University of Agder, Kristiansand, Norway.
Integr Cancer Ther. 2023 Jan-Dec;22:15347354231178869. doi: 10.1177/15347354231178869.
While moderate-to-vigorous intensity physical activity (MVPA) is associated with various health improvements shortly after completion of exercise interventions, it remains unclear which health benefits can be expected when MVPA levels are maintained in the long term in cancer survivors. We aimed to assess the associations of (1) MVPA level at 12-month follow-up and (2) long-term MVPA patterns (from immediately post-intervention to 12-month follow-up) with different cancer-related health outcomes.
In the Physical training and Cancer (Phys-Can) RCT, 577 participants diagnosed with breast (78%), prostate (19%), or colorectal (3%) cancer were randomized to 6 months of exercise during curative cancer treatment. Accelerometer-assessed physical activity and outcome data (ie, cancer-related fatigue, health-related quality of life [HRQoL], anxiety and depression, functioning in daily life, cardiorespiratory fitness, sedentary time and sleep) were collected immediately post-intervention and at 12-month follow-up. Based on the sample's median of MVPA immediately post-intervention (65 minutes/day) and the changes between the 2 measurement points, 4 categories with different long-term MVPA patterns were created: High & Increasing, High & Decreasing, Low & Increasing, and Low & Decreasing. Multiple linear regression analyses were performed for the analyses.
A total of 353 participants were included in the analyses. At 12-month follow-up, a higher MVPA level was significantly associated with lower fatigue in 3 domains (general fatigue [β = -.33], physical fatigue [β = -.53] and reduced activity [β = -.37]), higher cardiorespiratory fitness (β = .34) and less sedentary time (β = -.35). For long-term MVPA patterns, compared to the participants in the "Low & Decreasing" category, those in the "High & Increasing" category reported significantly lower fatigue in 3 domains (general fatigue [β = -1.77], physical fatigue [β = -3.36] and reduced activity [β = -1.58]), higher HRQoL (β = 6.84) and had less sedentary time (β = -1.23).
Our results suggest that long-term physical activity is essential for improving health outcomes post-intervention in cancer survivors. Cancer survivors, including those who reach recommended MVPA levels, should be encouraged to maintain or increase MVPA post-intervention for additional health benefits.
NCT02473003 (10/10/2014).
虽然中等到剧烈强度的身体活动（MVPA）与运动干预完成后不久的各种健康改善有关，但尚不清楚在癌症幸存者中长期保持 MVPA 水平时可以预期哪些健康益处。我们旨在评估（1）12 个月随访时的 MVPA 水平和（2）长期 MVPA 模式（从干预后即刻到 12 个月随访）与不同癌症相关健康结果之间的关联。
在 Physical training and Cancer（Phys-Can）RCT 中，577 名被诊断患有乳腺癌（78%）、前列腺癌（19%）或结直肠癌（3%）的患者被随机分配到癌症治疗期间进行 6 个月的运动。使用加速度计评估身体活动和结果数据（即癌症相关疲劳、健康相关生活质量[HRQoL]、焦虑和抑郁、日常生活功能、心肺功能适应性、久坐时间和睡眠），并在干预后即刻和 12 个月随访时进行收集。基于样本干预后即刻的 MVPA 中位数（65 分钟/天）和 2 个测量点之间的变化，创建了 4 个具有不同长期 MVPA 模式的类别：高且增加、高且减少、低且增加和低且减少。进行了多次线性回归分析。
共有 353 名参与者纳入分析。在 12 个月随访时，较高的 MVPA 水平与以下 3 个领域的疲劳程度降低显著相关（一般疲劳[β=-.33]、体力疲劳[β=-.53]和活动减少[β=-.37]）、心肺功能适应性更高（β=-.34）和久坐时间减少（β=-.35）。对于长期 MVPA 模式，与“低且减少”类别的参与者相比，“高且增加”类别的参与者在以下 3 个领域的疲劳程度明显较低（一般疲劳[β=-.17]、体力疲劳[β=-.33]和活动减少[β=-.15]），HRQoL 更高（β=6.84），久坐时间更少（β=-.12）。
我们的结果表明，长期的身体活动对于改善癌症幸存者干预后的健康结果至关重要。癌症幸存者，包括那些达到推荐 MVPA 水平的人，应该在干预后被鼓励保持或增加 MVPA，以获得额外的健康益处。
NCT02473003（2014 年 10 月 10 日）。
