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对2025年来自沙特阿拉伯、意大利的四名旅行者中引起侵袭性脑膜炎球菌病的W血清群进行基因组分析。

Genomic analysis of serogroup W causing invasive meningococcal disease in four travellers from Saudi Arabia, Italy, 2025.

作者信息

Neri Arianna, Taviani Elsa, Ferraro Federica, Maraglino Francesco, Marra Manuela, Daprai Laura, Vocale Caterina, Vian Elisa, Palamara Anna Teresa, Stefanelli Paola

机构信息

Department of Infectious Diseases, Istituto Superiore di Sanità (ISS), Rome, Italy.

Italian Ministry of Health, Rome, Italy.

出版信息

Euro Surveill. 2025 Aug;30(31). doi: 10.2807/1560-7917.ES.2025.30.31.2500483.

DOI:10.2807/1560-7917.ES.2025.30.31.2500483
PMID:40776895
Abstract

Genomic analysis was performed on isolates from four cases of invasive meningococcal disease (IMD) identified in Italy after travel to Saudi Arabia in 2025. The cases were not epidemiologically related. The isolates from the cases were whole genome sequenced and belonged to serogroup W, sequence type (ST)-11, clonal complex (CC)11 and were susceptible to ceftriaxone, ciprofloxacin, penicillin G and rifampicin. Phylogenetic analysis grouped the four genomes with the Hajj strain sublineage.

摘要

对2025年前往沙特阿拉伯后在意大利确诊的4例侵袭性脑膜炎球菌病(IMD)病例的分离株进行了基因组分析。这些病例在流行病学上无关联。对这些病例的分离株进行了全基因组测序,它们属于W血清群、序列型(ST)-11、克隆复合体(CC)11,并且对头孢曲松、环丙沙星、青霉素G和利福平敏感。系统发育分析将这四个基因组与朝觐菌株亚系归为一组。

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本文引用的文献

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Cases of Meningococcal Disease Associated with Travel to Saudi Arabia for Umrah Pilgrimage - United States, United Kingdom, and France, 2024.与前往沙特阿拉伯进行朝觐相关的脑膜炎球菌病病例 - 美国、英国和法国,2024 年。
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Cocirculation of Hajj and non-Hajj strains among serogroup W meningococci in Italy, 2000 to 2016.
2000 年至 2016 年期间,意大利血清群 W 脑膜炎奈瑟菌中朝觐和非朝觐菌株的共同循环。
Euro Surveill. 2019 Jan;24(4). doi: 10.2807/1560-7917.ES.2019.24.4.1800183.
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Rise in invasive serogroup W meningococcal disease in Australia 2013-2015.2013 - 2015年澳大利亚侵袭性W群脑膜炎球菌病发病率上升。
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Genomic Epidemiology of Hypervirulent Serogroup W, ST-11 Neisseria meningitidis.高毒力血清群W、ST-11型脑膜炎奈瑟菌的基因组流行病学
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