Li Xiaobing, Li Xuemei, Li Qin, Li Qian, Liu Yongsheng, Zhang Li, Wang Li
Science and Technology Industry Development Center, Chongqing Medical and Pharmaceutical College, Chongqing 401331, P.R. China.
Department of Occupational Disease and Poisoning Medicine, The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College, Chongqing 400060, P.R. China.
Exp Ther Med. 2025 Jul 23;30(3):180. doi: 10.3892/etm.2025.12930. eCollection 2025 Sep.
Multiple myeloma (MM) is a hematological malignancy characterized by the clonal expansion of malignant plasma cells within the bone marrow, leading to diverse systemic complications. While cutaneous manifestations of MM are uncommon, follicular spicules represent a highly specific but rare dermatological finding associated with MM. The present study presents the case of a 59-year-old man with MM who exhibited follicular acanthosis and hyperkeratosis as cutaneous indicators of the malignancy. The patient, with a history of stage 5 chronic kidney disease undergoing maintenance hemodialysis, was diagnosed with follicular spicules of MM (FSMM) through clinical evaluation and laboratory investigations. The present case highlights the clinical importance of recognizing rare cutaneous manifestations in MM, which can serve as critical diagnostic clues. Improved awareness of FSMM may facilitate a timely diagnosis and optimize patient management, ultimately contributing to improved clinical outcomes in this challenging population.
多发性骨髓瘤（MM）是一种血液系统恶性肿瘤，其特征是骨髓内恶性浆细胞的克隆性增殖，导致多种全身并发症。虽然MM的皮肤表现并不常见，但毛囊性棘状丘疹是与MM相关的一种高度特异性但罕见的皮肤病学表现。本研究报告了一例59岁的MM男性患者，其表现为毛囊性棘皮症和角化过度，作为该恶性肿瘤的皮肤指标。该患者有5期慢性肾病病史，正在接受维持性血液透析，通过临床评估和实验室检查被诊断为MM的毛囊性棘状丘疹（FSMM）。本病例突出了认识MM罕见皮肤表现的临床重要性，这些表现可作为关键的诊断线索。提高对FSMM的认识可能有助于及时诊断并优化患者管理，最终改善这一具有挑战性人群的临床结局。
