Kefeli Ayşe, Onayrılı Feyyaz, Gokcal Fahri
Tokat Gaziosmanpasa University, Gastroenterology Department, Gaziosmanpasa, Tokat, Turkiye.
Tokat Gaziosmanpasa University, Internal Medicine, Gaziosmanpasa, Tokat, Turkiye.
Afr Health Sci. 2024 Sep;24(3):205-215. doi: 10.4314/ahs.v24i3.25.
We aimed to determine whether complete blood count(CBC) parameters, such as the white blood count(WBC), hemoglobin(Hb), platelet(PLT), red cell distribution width(RDW), mean platelet volume(MPV), platelet distribution width(PDW), neutrophil-to-lymphocyte ratio(NLR), platelet-to-lymphocyte ratio(PLR), and monocyte-to-lymphocyte ratio(MLR), have a predictive value in the detection of gastric cancer(GC) and intestinal metaplasia(IM).
While proven GC, IM, and healthy control(HC) patients were included, patients with the comorbid disease were excluded, and univariate analyses compared three groups. The receiver operating characteristic(ROC) curve analysis was run for CBC parameters. The area under the curve(AUC) was evaluated, and a cut-off value was determined. The sensitivity and specificity of each parameter were considered.
The GC, IM, and HC groups consisted of 72(33%), 73(34%), and 72(33%) patients, respectively. RDW, PLT, NLR, PLR, and MLR were significant between GC and IM. The highest AUC (0.727) was obtained for the PLT yielding a 56.9% sensitivity and 79.4% specificity at a cut-off value of 151.8. The AUC of RDW was found as 0.691 and 0.626 for pairwise comparisons of GC-HC and IM-HC, respectively. At a cut-off value of 13.4, PLR yielded 70.8% sensitivity and 61.1% specificity in the detection of GC, while 64.4% sensitivity and 51.1% specificity for IM.
CBC parameters, such as RDW, PLT, NLR, PLR, and MLR, have value in detecting GC. RDW also has diagnostic value in helping to detect IM. PLR can help to distinguish patients with GC from those with IM. These inexpensive, easily accessible parameters may help in the timely diagnosis of GC and IM.
我们旨在确定全血细胞计数（CBC）参数，如白细胞计数（WBC）、血红蛋白（Hb）、血小板（PLT）、红细胞分布宽度（RDW）、平均血小板体积（MPV）、血小板分布宽度（PDW）、中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）以及单核细胞与淋巴细胞比值（MLR），在胃癌（GC）和肠化生（IM）检测中是否具有预测价值。
纳入经证实的GC、IM和健康对照（HC）患者，排除患有合并症的患者，单因素分析对三组进行比较。对CBC参数进行受试者操作特征（ROC）曲线分析。评估曲线下面积（AUC）并确定临界值。考虑每个参数的敏感性和特异性。
GC组、IM组和HC组分别由72例（33%）、73例（34%）和72例（33%）患者组成。RDW、PLT、NLR、PLR和MLR在GC组和IM组之间存在显著差异。PLT的AUC最高（0.727），在临界值为151.8时，敏感性为56.9%，特异性为79.4%。GC与HC、IM与HC的两两比较中，RDW的AUC分别为0.691和0.626。在临界值为13.4时，PLR在检测GC时敏感性为70.8%，特异性为61.1%，在检测IM时敏感性为64.4%，特异性为51.1%。
RDW、PLT、NLR、PLR和MLR等CBC参数在检测GC方面具有价值。RDW在帮助检测IM方面也具有诊断价值。PLR有助于区分GC患者和IM患者。这些廉价、易于获取的参数可能有助于GC和IM的及时诊断。
