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使用癌症表位数据库和分析资源(CEDAR)。

Using the Cancer Epitope Database and Analysis Resource (CEDAR).

作者信息

Koşaloğlu-Yalçın Zeynep, Vita Randi, Blazeska Nina, Peters Bjoern, Sette Alessandro

机构信息

Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.

Department of Medicine, University of California San Diego, La Jolla, CA, USA.

出版信息

Methods Mol Biol. 2025;2932:75-91. doi: 10.1007/978-1-0716-4566-6_3.

Abstract

The Cancer Epitope Database and Analysis Resource (CEDAR) is a freely accessible catalog of cancer epitope and receptor data linked to the biological, immunological, and clinical contexts in which they were described. CEDAR data is populated by manual curation of the cancer literature and provides a central resource for researchers to access information about cancer antigens and their specific epitopes, which is relevant to our understanding of the role that the immune system plays in cancer progression, prevention, and treatment. In this chapter, we aim to provide a comprehensive overview of the database section of CEDAR. This includes a detailed description of all available query parameters, guidance on navigating through the query results, and a demonstration of how CEDAR can aid cancer research, featuring example research scenarios and queries.

摘要

癌症表位数据库与分析资源(CEDAR)是一个可免费访问的目录,收录了与所描述的生物学、免疫学和临床背景相关的癌症表位和受体数据。CEDAR数据通过人工筛选癌症文献来填充,为研究人员提供了一个核心资源,以便获取有关癌症抗原及其特定表位的信息,这与我们理解免疫系统在癌症进展、预防和治疗中所起的作用相关。在本章中,我们旨在全面概述CEDAR的数据库部分。这包括对所有可用查询参数的详细描述、浏览查询结果的指南,以及展示CEDAR如何助力癌症研究,并列举示例研究场景和查询。

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