Lim Jungeun, Chang Che-Jung, White Alexandra J, Lo Shelton, Wang Hantao, Goodney Gabriel A, Miao Rui, Barochia Amisha V, Roger Véronique L, Sandler Dale P, Wong Jason Y Y
Epidemiology and Community Health Branch, National Heart, Lung, and Blood Institute, Bethesda, MD, USA.
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Environ Int. 2025 Aug;202:109681. doi: 10.1016/j.envint.2025.109681. Epub 2025 Jul 11.
Population studies have found associations between prenatal exposure to endocrine-disrupting chemicals (EDCs) in personal care products (PCPs) and childhood asthma; however, few have examined adult-onset asthma. We investigated the associations between commonly used PCPs and the risk of adult-onset asthma in a prospective cohort study of U.S. women.
We analyzed 39,408 participants from the Sister Study who self-reported their usage frequency of 41 PCPs in the 12-month period before baseline (2003-2009). In our combined PCP analyses, we used Least Absolute Shrinkage and Selection Operator (LASSO) to select key PCPs that predict the risk of adult-onset asthma. In group-specific analyses, PCPs were aggregated into four product groups (i.e., beauty, everyday hair, hygiene, and skincare products). Subsequently, we conducted latent class analysis to identify groups of participants with similar patterns of PCP use (e.g., infrequent (reference), moderate, and frequent). Multivariable Cox regression models were used to assess the associations between PCP use and incident adult-onset asthma.
Over an average 12.5-year follow-up, 1,774 incident asthma cases were identified. We found a positive association between combined PCP use and adult-onset asthma risk (moderate users, hazard ratio [HR] = 1.19 (95% confidence interval (CI):1.05,1.33) and frequent users, HR = 1.19 (95% CI:1.06,1.34)). In group-specific analyses, moderate (HR = 1.21 (95% CI:1.07,1.37)) and frequent (HR = 1.22 (95% CI:1.08,1.38)) users of beauty products had higher asthma risk compared to infrequent users. Similar associations were observed for hygiene (moderate: HR = 1.14 (95% CI:1.01,1.29) and frequent: HR = 1.20 (95% CI:1.06,1.36)) and skincare products (moderate: HR = 1.21 (95% CI:1.06,1.38) and frequent: HR = 1.20 (95% CI:1.06,1.35)).
Our findings suggest that PCP use potentially contributes to future risk of adult-onset asthma among women.
人群研究发现，孕期接触个人护理产品（PCP）中的内分泌干扰化学物质（EDC）与儿童哮喘之间存在关联；然而，很少有研究探讨成人期哮喘。我们在美国女性前瞻性队列研究中调查了常用PCP与成人期哮喘风险之间的关联。
我们分析了来自姐妹研究的39408名参与者，她们在基线（2003 - 2009年）前12个月内自我报告了41种PCP的使用频率。在我们的综合PCP分析中，我们使用最小绝对收缩和选择算子（LASSO）来选择预测成人期哮喘风险的关键PCP。在特定产品组分析中，PCP被汇总为四个产品组（即美容、日常头发、卫生和护肤品）。随后，我们进行了潜在类别分析，以识别PCP使用模式相似的参与者组（例如，不频繁使用（参考）、中等使用和频繁使用）。多变量Cox回归模型用于评估PCP使用与成人期哮喘发病之间的关联。
在平均12.5年的随访中，共识别出1774例哮喘发病病例。我们发现综合使用PCP与成人期哮喘风险呈正相关（中等使用者，风险比[HR]=1.19（95%置信区间[CI]：1.05,1.33）；频繁使用者，HR = 1.19（95% CI：1.06,1.34））。在特定产品组分析中，与不频繁使用者相比，美容产品的中等使用者（HR = 1.21（95% CI：1.07,1.37））和频繁使用者（HR = 1.22（95% CI：1.08,1.38））患哮喘的风险更高。卫生产品（中等使用：HR = 1.14（95% CI：1.01,1.29）；频繁使用：HR = 1.20（95% CI：1.06,1.36））和护肤品（中等使用：HR = 1.21（95% CI：1.06,1.38）；频繁使用：HR = 1.20（95% CI：1.06,1.35））也观察到类似的关联。
我们的研究结果表明，使用PCP可能会增加女性未来患成人期哮喘的风险。
