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本文引用的文献

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Behavioral analysis in laboratory rats: Challenges and usefulness of 50-kHz ultrasonic vocalizations.实验室大鼠的行为分析:50kHz 超声发声的挑战和用途。
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2
Excessive Laughter-like Vocalizations, Microcephaly, and Translational Outcomes in the Deletion Rat Model of Angelman Syndrome.过度大笑样发声、小头畸形和 Angelman 综合征缺失鼠模型的转译结果。
J Neurosci. 2021 Oct 20;41(42):8801-8814. doi: 10.1523/JNEUROSCI.0925-21.2021. Epub 2021 Sep 2.
3
Biological Functions of Rat Ultrasonic Vocalizations, Arousal Mechanisms, and Call Initiation.大鼠超声波发声的生物学功能、唤醒机制及叫声起始
Brain Sci. 2021 May 9;11(5):605. doi: 10.3390/brainsci11050605.
4
Ultrasonic Vocalizations as a Measure of Affect in Preclinical Models of Drug Abuse: A Review of Current Findings.超声发声作为药物滥用临床前模型中情感的一种测量方法:当前研究结果综述
Curr Neuropharmacol. 2015;13(2):193-210. doi: 10.2174/1570159x13999150318113642.
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Phasic dopamine release in the nucleus accumbens in response to pro-social 50 kHz ultrasonic vocalizations in rats.大鼠社交性 50 kHz 超声发声刺激引起伏隔核中多巴胺的相位释放。
J Neurosci. 2014 Aug 6;34(32):10616-23. doi: 10.1523/JNEUROSCI.1060-14.2014.
6
Direct and long-lasting effects elicited by repeated drug administration on 50-kHz ultrasonic vocalizations are regulated differently: implications for the study of the affective properties of drugs of abuse.反复给予药物对 50-kHz 超声波发声的直接和持久影响受到不同的调节:对滥用药物情感属性研究的影响。
Int J Neuropsychopharmacol. 2014 Mar;17(3):429-41. doi: 10.1017/S1461145713001235. Epub 2013 Oct 21.
7
Laughing rats are optimistic.开心的老鼠通常都很乐观。
PLoS One. 2012;7(12):e51959. doi: 10.1371/journal.pone.0051959. Epub 2012 Dec 26.
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Frequency-modulated 50 kHz ultrasonic vocalizations: a tool for uncovering the molecular substrates of positive affect.调频 50 kHz 超声发声:揭示积极情感分子基础的工具。
Neurosci Biobehav Rev. 2011 Oct;35(9):1831-6. doi: 10.1016/j.neubiorev.2010.11.011. Epub 2010 Dec 7.
9
The effects of selective breeding for differential rates of 50-kHz ultrasonic vocalizations on emotional behavior in rats.针对50千赫超声波发声的不同速率进行选择性育种对大鼠情绪行为的影响。
Dev Psychobiol. 2009 Jan;51(1):34-46. doi: 10.1002/dev.20343.
10
Tickling-induced 50-kHz ultrasonic vocalization is individually stable and predicts behaviour in tests of anxiety and depression in rats.挠痒诱发的50千赫兹超声波发声具有个体稳定性,并能预测大鼠焦虑和抑郁测试中的行为。
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我们是如何偶然发现大鼠玩耍时的发声的:一段回忆。

How we stumbled upon the rat play vocalizations: A recollection.

作者信息

Knutson Brian

机构信息

Psychology and Neuroscience, Stanford University, United States.

出版信息

Behav Brain Res. 2025 Aug 7;495:115773. doi: 10.1016/j.bbr.2025.115773.

DOI:10.1016/j.bbr.2025.115773
PMID:40780459
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12366628/
Abstract

Over a quarter of a century later, most rodent researchers know that specific types of rat Ultrasonic Vocalizations (USVs) appear to index distinct affective states endowed with arousal, value, and motivational force. Few know the story, however, of how we accidentally stumbled upon 50 kilohertz (50 kHz) USVs in the context of rat play by turning the wrong dial on a bat detector, which I recollect here. The tale of that mistake highlights the critical roles of serendipity, preparation, openness, persistence, and a supportive environment in scientific discovery.

摘要

二十五年多后,大多数啮齿动物研究人员都知道,特定类型的大鼠超声波发声(USV)似乎能够指示出具有唤醒、价值和驱动力的不同情感状态。然而,很少有人知道我们是如何在大鼠玩耍的情境中,通过在蝙蝠探测器上误拨了一个旋钮,意外发现了50千赫兹(50kHz)的超声波发声,我在此回忆一下这个故事。那个错误的故事凸显了意外发现、准备、开放心态、坚持以及支持性环境在科学发现中的关键作用。