McLeod W A, Winkelmann R K
J Am Acad Dermatol. 1985 Dec;13(6):952-8. doi: 10.1016/s0190-9622(85)70244-7.
Five patients are reported on whose clinical skin disease consisted of polymorphous papulonodular lesions healing with a depigmented scar. Although all cases had been termed lymphomatoid papulosis after clinical or histologic examination, the lesions consisted principally of masses of histiocytes and eosinophils. Individual lesions healed spontaneously or with minimal treatment, but the chronic course of disease was not altered by any therapy used. Follow-up 3 to 17 years later indicated persistent or recurrent disease, and one patient died of histiocytic malignancy. Eosinophilic histiocytosis is the microscopic picture of an unusual group of patients with chronic papulonodular necrotic skin disease that may deserve to be considered a disease pattern per se.
报告了5例患者，其临床皮肤病表现为多形性丘疹结节性损害，愈合后留有色素脱失性瘢痕。尽管所有病例经临床或组织学检查后均被诊断为淋巴瘤样丘疹病，但损害主要由组织细胞和嗜酸性粒细胞团块组成。单个损害可自行愈合或经极少治疗后愈合，但所用的任何治疗均未改变疾病的慢性病程。3至17年后的随访表明疾病持续或复发，1例患者死于组织细胞恶性肿瘤。嗜酸性组织细胞增多症是一组患有慢性丘疹结节性坏死性皮肤病的特殊患者的显微镜表现，可能本身就值得被视为一种疾病类型。
