Wei Jinwen, Zou Huiru, Tang Qianyuan, Yao Ziqing, Huang Gan, Liang Zhen, Zhang Li, Ren Lijie, Cai Xiaodong, Yao Chen, Zhou Changsong, Zhang Zhiguo
School of Intelligence Science and Engineering, Harbin Institute of Technology, Shenzhen, Guangdong, China.
School of Biomedical Engineering, Medical School, Shenzhen University, Shenzhen, China.
Commun Biol. 2025 Aug 8;8(1):1182. doi: 10.1038/s42003-025-08600-z.
Visual variability is linked to prestimulus alpha (8-13 Hz) and beta (13-30 Hz) power fluctuations, yet their causal role remains unclear. Using transcranial random noise stimulation (tRNS), we tested whether externally modulating cortical excitability could influence these oscillations and alter perception. In a sham-controlled, within-subject design, 29 participants completed a visual detection task combined with electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS) recordings. Mental fatigue was modelled as a state-dependent factor. tRNS, primarily under low fatigue, increased online oxyhemoglobin (HbO) amplitude, suppressed offline prestimulus alpha and beta power, and reduced offline visual contrast threshold (VCT), indicating enhanced perception. Further analyses revealed that fatigue influenced the oscillations' responsiveness to tRNS, and that under low fatigue, alpha power, more than beta, demonstrated greater functional sensitivity to VCT. These findings demonstrate that tRNS can improve perception by modulating alpha/beta oscillations in specific brain states, highlighting the role of brain state in neuromodulation efficacy.
视觉变异性与刺激前的阿尔法（8 - 13赫兹）和贝塔（13 - 30赫兹）功率波动有关，但其因果作用仍不清楚。我们使用经颅随机噪声刺激（tRNS），测试了外部调节皮层兴奋性是否会影响这些振荡并改变感知。在一项假刺激对照的受试者内设计中，29名参与者完成了一项视觉检测任务，并结合脑电图（EEG）和功能性近红外光谱（fNIRS）记录。将精神疲劳建模为一个状态依赖性因素。tRNS主要在低疲劳状态下，增加了在线氧合血红蛋白（HbO）振幅，抑制了离线刺激前的阿尔法和贝塔功率，并降低了离线视觉对比度阈值（VCT），表明感知增强。进一步分析表明，疲劳影响了振荡对tRNS的反应性，并且在低疲劳状态下，阿尔法功率比贝塔功率对VCT表现出更高的功能敏感性。这些发现表明，tRNS可以通过在特定脑状态下调节阿尔法/贝塔振荡来改善感知，突出了脑状态在神经调节功效中的作用。
