Chandra S V, Kalia K, Hussain T
J Appl Toxicol. 1985 Dec;5(6):378-81. doi: 10.1002/jat.2550050608.
Diabetic rats (alloxan diabetes) were exposed to cadmium (2 mg kg-1 i.p.) daily for 21 days to investigate the levels of blood glucose, biogenic amines and iron, copper, zinc and cadmium in the brain. Cadmium exposure to diabetic rats produced a significant exacerbation in the hyperglycemic effect and accumulation of cadmium in the blood compared with that observed after diabetes or cadmium exposure alone. The elevation in the levels of brain dopamine and 5-hydroxytryptamine were also more pronounced in cadmium-exposed diabetic rats compared with either cadmium exposure or diabetes alone. Cadmium exposure to diabetic rats also produced significant changes in the concentrations of copper in the blood. These results indicated enhanced cadmium toxicity in diabetic rats.
将糖尿病大鼠（四氧嘧啶糖尿病模型）每天腹腔注射镉（2毫克/千克），持续21天，以研究血糖、生物胺以及大脑中铁、铜、锌和镉的水平。与单独患糖尿病或单独接触镉相比，糖尿病大鼠接触镉后，高血糖效应显著加剧，血液中镉的蓄积增加。与单独接触镉或患糖尿病相比，接触镉的糖尿病大鼠大脑中多巴胺和5-羟色胺水平的升高也更为明显。糖尿病大鼠接触镉还导致血液中铜浓度发生显著变化。这些结果表明糖尿病大鼠中镉的毒性增强。
