Winklbauer R, Hausen P
J Embryol Exp Morphol. 1985 Aug;88:183-92.
During normal development of the supraorbital lateral line system of Xenopus, an elongated streak of primordial cells becomes subdivided into a linear series of cell groups containing only about eight cells each, thus forming a row of primary lateral line organs (Winklbauer & Hausen, 1983a,b). In triploid Xenopus embryos, cell size is 1.5 X normal. When the formation of lateral line organs occurs in triploid primordia, the nascent organs contain only about five or six cells each, i.e. about two thirds of normal. Thus, the increase in cell size is compensated for by a corresponding reduction in cell number, keeping constant the organ size in terms of total cell mass or volume. This result excludes a cell counting mechanism for determining organ size. In diploids, the primary organs, although being of equal size initially, differ vastly in their final size and exhibit a peculiar frequency distribution of organ sizes. A detailed quantitative model for supraorbital lateral line development has been proposed, which accounts for this characteristic frequency distribution (Winklbauer & Hausen, 1983b). This model makes precise predictions as to the frequency distribution of the final size of triploid lateral line organs, where the initial organ size is reduced to five or six cells. These predictions were verified experimentally.
在非洲爪蟾眶上侧线系统的正常发育过程中，一条细长的原始细胞带会被细分为一系列线性排列的细胞群，每个细胞群仅包含约八个细胞，从而形成一排初级侧线器官（Winklbauer和Hausen，1983a，b）。在三倍体非洲爪蟾胚胎中，细胞大小是正常的1.5倍。当三倍体原基中侧线器官形成时，新生器官每个仅包含约五六个细胞，即约为正常数量的三分之二。因此，细胞大小的增加被细胞数量的相应减少所补偿，使得器官在总细胞质量或体积方面的大小保持恒定。这一结果排除了一种用于确定器官大小的细胞计数机制。在二倍体中，初级器官虽然最初大小相等，但最终大小差异很大，并且呈现出一种特殊的器官大小频率分布。已经提出了一个关于眶上侧线发育的详细定量模型，该模型解释了这种特征频率分布（Winklbauer和Hausen，1983b）。这个模型对三倍体侧线器官最终大小的频率分布做出了精确预测，其中初始器官大小减少到五六个细胞。这些预测通过实验得到了验证。
