Winklbauer R, Hausen P
J Embryol Exp Morphol. 1983 Aug;76:265-81.
During development of Xenopus laevis, the supraorbital lateral line system (i.e. the parietal and supraorbital lines of organs and the anterior auditory group of organs) is all derived from a single primordium located in the ear region of the epidermis. The primordium elongates first by active movement along the dorsal margin of the eye. Individual primary organs are then formed by progressive fragmentation of the streak-like primordium. After fragmentation, passive displacement of the organs due to skin growth seems to play the main role in altering the arrangement of the line system. Transplantation experiments confirmed that non-placodal epidermal cells are not incorporated into the developing system. The active elongation of the primordium is due to cell multiplication, and not due to cell rearrangement or change in cell shape or size. Cell multiplication is not confined to a growth zone, but dividing cells are randomly distributed throughout the primordium. All cells of a primordium have to change position during its elongation.
在非洲爪蟾的发育过程中，眶上侧线系统（即器官的顶线和眶上线以及器官的前听觉组）均源自位于表皮耳部区域的单个原基。原基首先通过沿眼背缘的主动运动而伸长。然后，通过条带状原基的逐渐碎片化形成单个初级器官。碎片化之后，由于皮肤生长导致的器官被动移位似乎在改变线系统的排列中起主要作用。移植实验证实，非基板表皮细胞不会整合到发育中的系统中。原基的主动伸长是由于细胞增殖，而不是由于细胞重排或细胞形状或大小的变化。细胞增殖并不局限于生长区，而是分裂细胞随机分布在整个原基中。原基的所有细胞在其伸长过程中都必须改变位置。
