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面部和颈部除皱术后急性局限性脓疱性银屑病：一个抵抗力较弱部位的病例

Acute Localized Exanthematous Pustulosis After Face and Neck Rhytidectomy: A Case of Locus Minoris Resistentiae.

作者信息

Fort Liliana, Seminario-Vidal Lucia, Pepper Amber N, Billington Alicia

机构信息

From the Shorecrest Preparatory School, St. Petersburg, FL.

Weinkle Dermatology, Bradenton, FL.

出版信息

Plast Reconstr Surg Glob Open. 2025 Aug 8;13(8):e7052. doi: 10.1097/GOX.0000000000007052. eCollection 2025 Aug.

DOI:10.1097/GOX.0000000000007052
PMID:40786140
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12333704/
Abstract

We report a case of a 52-year-old woman who developed acute localized exanthematous pustulosis, a rare drug reaction, after cefazolin administration for a face and neck surgery. The rash was confined to the surgical areas, suggesting a locus minoris resistentiae, a phenomenon where a site of previous injury becomes more vulnerable to a subsequent insult. The rash resolved with corticosteroids. We review the clinical features, causes, and management of acute localized exanthematous pustulosis.

摘要

我们报告了一例52岁女性病例，该患者在接受面部和颈部手术后因使用头孢唑林而发生急性局限性脓疱性皮疹，这是一种罕见的药物反应。皮疹局限于手术区域，提示存在抵抗力较弱部位，即先前受伤部位更容易受到后续损伤的现象。皮疹通过使用皮质类固醇得以消退。我们对急性局限性脓疱性皮疹的临床特征、病因及治疗进行了综述。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ac/12333704/6a2110a39601/gox-13-e7052-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ac/12333704/4a3a9dac2132/gox-13-e7052-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ac/12333704/a798d6316aa5/gox-13-e7052-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ac/12333704/98215b0994fd/gox-13-e7052-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ac/12333704/6a2110a39601/gox-13-e7052-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ac/12333704/4a3a9dac2132/gox-13-e7052-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ac/12333704/a798d6316aa5/gox-13-e7052-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ac/12333704/98215b0994fd/gox-13-e7052-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10ac/12333704/6a2110a39601/gox-13-e7052-g004.jpg

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本文引用的文献

1
Acute localized exanthematous pustulosis because of cefixime in a child: case report and review of pediatric cases.一名儿童因头孢克肟引起急性局限性脓疱性皮疹：病例报告及儿科病例回顾
Int J Dermatol. 2022 Jun;61(6):707-709. doi: 10.1111/ijd.16044. Epub 2022 Jan 7.
2
Acute localized exanthematous pustulosis: Clinical features, pathophysiology, and therapy.急性局限性发疹性脓疱病：临床特征、发病机制和治疗。
Dermatol Ther. 2021 Sep;34(5):e15087. doi: 10.1111/dth.15087. Epub 2021 Aug 25.
3
Chlorhexidine Hypersensitivity: A Case Report of Delayed Reactions Associated with Epidermal Preparations.
洗必泰超敏反应：一例与表皮制剂相关的迟发反应病例报告
Plast Reconstr Surg Glob Open. 2020 Aug 14;8(8):e2945. doi: 10.1097/GOX.0000000000002945. eCollection 2020 Aug.
4
Cutaneous Eruption Secondary to Immunotherapy for Metastatic Melanoma Limited to Sites of Locoregional Melanoma Metastases: A Possible Variant of Locus Minoris Resistentiae.转移性黑色素瘤免疫治疗继发的皮肤疹局限于局部区域黑色素瘤转移部位：一种可能的抵抗力较弱部位变体
JAMA Dermatol. 2018 Jul 1;154(7):846-847. doi: 10.1001/jamadermatol.2018.0654.
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Acute Localized Exanthematous Pustulosis (ALEP): Review of Literature with Report of Case Caused by Amoxicillin-Clavulanic Acid.急性局限性脓疱性皮疹（ALEP）：文献综述及阿莫西林-克拉维酸所致病例报告
Dermatol Ther (Heidelb). 2017 Dec;7(4):563-570. doi: 10.1007/s13555-017-0206-1. Epub 2017 Oct 19.
6
An acneiform eruption exhibiting locus minoris resistentiae after whole-brain radiation and vemurafenib therapy.全脑放疗和维莫非尼治疗后出现抵抗力较弱部位的痤疮样皮疹。
J Eur Acad Dermatol Venereol. 2017 Apr;31(4):e209-e210. doi: 10.1111/jdv.13964. Epub 2016 Oct 20.
7
Contact allergy to chlorhexidine in a tertiary dermatology clinic in Denmark.丹麦一家三级皮肤科诊所中氯己定引发的接触过敏。
Contact Dermatitis. 2016 Jan;74(1):29-36. doi: 10.1111/cod.12487. Epub 2015 Nov 11.
8
Locus minoris resistentiae: An old but still valid way of thinking in medicine.抵抗力较弱部位：医学中一种古老但仍然有效的思维方式。
Clin Dermatol. 2014 Sep-Oct;32(5):553-6. doi: 10.1016/j.clindermatol.2014.04.001.
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