Naghsh Narges, Mogharehabed Ahmad, Amini Elham, Sahebkar Amirhossein
Department of Periodontics, Dental Implants Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
Dental Students' Research Committee, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
Dent Res J (Isfahan). 2025 Jul 24;22:31. doi: 10.4103/drj.drj_499_24. eCollection 2025.
This study aimed to compare the efficacy of casein phosphopeptide-amorphous calcium phosphate fluoride (CPP-ACPF) and propolis-based herbal toothpaste in the treatment of dentin hypersensitivity (DH).
In this clinical trial, 20 patients (7 men and 13 women) who met the inclusion criteria were randomly divided into two groups. One group received the herbal toothpaste containing propolis (Herbex), while the other received a paste containing CPP-ACPF (GC MI-Paste Plus). Two nonadjacent teeth with DH in two quadrants of each patient were assessed. The pain was determined through the visual analog scale (VAS) in cold and airblast tests before the intervention (baseline) as well as at 15 min, 1, 2, 4, and 8 weeks after the first application. Three-level mixed effect model (repeated measurement, tooth, and patients) was used to analyze the VAS score data. Estimation of fixed effect parameters with standard error and the intraclass correlation coefficient that quantifies the degree to which data at the lower level are correlated were reported. The statistical significance level was determined as < 0.05.
The mean pain intensity score after 8 weeks significantly decreased in the propolis-based toothpaste group ( < 0.001) and CPP-ACPF paste group ( < 0.001) compared with baseline. Betweenn-group comparison in the 8 week showed a significantly lower pain score in the propolis-based toothpaste group compared with the CPP-ACPF-containing paste ( = 0.02). However, at other intervals, there were no significant differences between the two groups ( > 0.05).
The use of both herbal toothpaste containing propolis and CPP-ACPF-containing paste for 8 weeks effectively reduced DH, with a higher desensitizing effect experienced in the former group.
本研究旨在比较酪蛋白磷酸肽 - 无定形磷酸钙氟化物（CPP - ACPF）和蜂胶基草本牙膏治疗牙本质过敏症（DH）的疗效。
在这项临床试验中，20名符合纳入标准的患者（7名男性和13名女性）被随机分为两组。一组使用含蜂胶的草本牙膏（Herbex），另一组使用含CPP - ACPF的牙膏（GC MI - Paste Plus）。评估每位患者两个象限中两颗不相邻的患牙本质过敏症的牙齿。在干预前（基线）以及首次应用后15分钟、1、2、4和8周，通过视觉模拟量表（VAS）在冷刺激和吹气试验中测定疼痛程度。采用三级混合效应模型（重复测量、牙齿和患者）分析VAS评分数据。报告固定效应参数的估计值及其标准误差，以及量化较低水平数据相关性程度的组内相关系数。统计学显著性水平设定为<0.05。
与基线相比，8周后蜂胶基牙膏组（<0.001）和CPP - ACPF牙膏组（<0.001）的平均疼痛强度评分显著降低。8周时两组间比较显示，蜂胶基牙膏组的疼痛评分显著低于含CPP - ACPF的牙膏组（=0.02）。然而，在其他时间间隔，两组之间无显著差异（>0.05）。
使用含蜂胶的草本牙膏和含CPP - ACPF的牙膏8周均能有效减轻牙本质过敏症，且前一组的脱敏效果更佳。
