Mahmoudlou Fatemeh, Tayebi Pouya, Moghadamnia Ali Akbar, Bijani Ali
Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
Department of Vascular and Endovascular Surgery, Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran.
Caspian J Intern Med. 2025 Jun 23;16(3):500-506. doi: 10.22088/cjim.16.3.500. eCollection 2025 Summer.
The maturation of the arteriovenous fistula (AVF) is necessary for successful hemodialysis treatment. However, the role of antihypertensive drugs in influencing AVF maturation remains uncertain. This study investigated the AVF maturation in patients with renal failure treated with antihypertensive medications.
A prospective cohort study was conducted on 73 patients who needed to be treated with hemodialysis through AVF. Demographic information, medication, underlying diseases, blood pressure changes, surgical information, and the time of AVF maturation were collected during the study. Descriptive statistics and survival analysis were employed to assess the outcomes.
The mean age of patients was 53.96±13.65 years, with 38 (52.1%) males and 35 (47.9%) females. The mean AVF maturation time was 104.87±1.02 days, and the rate of AVF maturation was 87.7%. Among the comorbidities, the rate of AVF maturation in diabetic patients (78.4%) versus non-diabetic (97.2%) exhibited a notably diminished effect (P = 0.028). There was a significant association between mean intraoperative arterial blood pressure (123.45±2.89 mmHg) and AVF maturation time (P = 0.033). Furthermore, there were not any significant differences in the use of antihypertensive medications on AVF maturation time or rates.
Our study findings suggest that the administration of antihypertensive medications did not demonstrate a significant correlation with either the AVF maturation outcome or the time required for maturation.
动静脉内瘘（AVF）成熟是成功进行血液透析治疗的必要条件。然而，抗高血压药物在影响AVF成熟方面的作用仍不明确。本研究调查了接受抗高血压药物治疗的肾衰竭患者的AVF成熟情况。
对73例需要通过AVF进行血液透析治疗的患者进行了一项前瞻性队列研究。在研究期间收集了人口统计学信息、用药情况、基础疾病、血压变化、手术信息以及AVF成熟时间。采用描述性统计和生存分析来评估结果。
患者的平均年龄为53.96±13.65岁，男性38例（52.1%），女性35例（47.9%）。AVF的平均成熟时间为104.87±1.02天，AVF成熟率为87.7%。在合并症中，糖尿病患者的AVF成熟率（78.4%）与非糖尿病患者（97.2%）相比明显降低（P = 0.028）。术中平均动脉血压（123.45±2.89 mmHg）与AVF成熟时间之间存在显著关联（P = 0.033）。此外，使用抗高血压药物对AVF成熟时间或成熟率没有任何显著差异。
我们的研究结果表明，抗高血压药物的使用与AVF成熟结果或成熟所需时间均无显著相关性。
