Aboutorabi Robab, Hariri Golrokh, Mazloum Khorasani Zahra, Mehrad-Majd Hassan
Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Internal Medicine, School of Medicine, Neyshabur University of Medical Sciences, Neyshabur, Iran.
Caspian J Intern Med. 2025 Jun 23;16(3):493-499. doi: 10.22088/cjim.16.3.493. eCollection 2025 Summer.
Irisin, a myokine implicated in metabolic hemostasis, have been investigated in relation to type 2 diabetes mellitus (T2DM), yet findings on its serum levels and association with diabetic complications such as nephropathy remain inconsistent. This study aimed to assess the relationship between serum irisin levels and renal function in T2DM patients.
A cross-sectional study was conducted involving 140 individuals diagnosed with T2DM. Demographic, anthropometric, and clinical data were recorded. Fasting blood samples were collected to determine serum irisin levels using the ELISA method. Additional biochemical measurements included fasting blood glucose, creatinine, HDL, LDL, triglycerides, HbA1c, and urinary albumin. Correlations between irisin levels and these parameters were analyzed. Patients were divided into two groups based on glomerular filtration rate (GFR) and albumin-to-creatinine ratio (ACR) to assess associations between irisin levels and renal function.
No statistically significant difference in serum irisin levels was observed between patients with reduced renal function (GFR≤60) and those with GFR>60 (10.45±6.54 vs. 13.32±10.59 ng/ml, P=0.08). In stratified analysis by ACR, patients with nephropathy displayed a non-significantly lower irisin level than those without (11.70±8.18 vs. 13.38±11.51, P=0.33). Serum irisin showed no significant correlations with FBS (P=0.05), insulin (P=0.06), LDL (P=0.96), HDL (P=0.61), or BMI (P=0.42).
Lower irisin levels in T2DM patients with reduced renal function or nephropathy may indicate a potential role for irisin in diabetic renal disease progression. Serum irisin could serve as a prognostic biomarker for diabetic nephropathy pending further validation.
鸢尾素是一种与代谢稳态相关的肌动蛋白，已针对2型糖尿病（T2DM）进行了研究，但其血清水平及与糖尿病并发症（如肾病）的关联研究结果仍不一致。本研究旨在评估T2DM患者血清鸢尾素水平与肾功能之间的关系。
进行了一项横断面研究，纳入140例诊断为T2DM的个体。记录人口统计学、人体测量学和临床数据。采集空腹血样，采用ELISA法测定血清鸢尾素水平。其他生化指标包括空腹血糖、肌酐、高密度脂蛋白、低密度脂蛋白、甘油三酯、糖化血红蛋白和尿白蛋白。分析鸢尾素水平与这些参数之间的相关性。根据肾小球滤过率（GFR）和白蛋白与肌酐比值（ACR）将患者分为两组，以评估鸢尾素水平与肾功能之间的关联。
肾功能降低（GFR≤60）的患者与GFR>60的患者之间血清鸢尾素水平无统计学显著差异（10.45±6.54对13.32±10.59 ng/ml，P=0.08）。在按ACR进行的分层分析中，肾病患者的鸢尾素水平略低于无肾病患者，但无统计学显著差异（11.70±8.18对13.38±11.51，P=0.33）。血清鸢尾素与空腹血糖（P=0.05）、胰岛素（P=0.06）、低密度脂蛋白（P=0.96）、高密度脂蛋白（P=0.61）或体重指数（P=0.42）均无显著相关性。
肾功能降低或患有肾病的T2DM患者鸢尾素水平较低，这可能表明鸢尾素在糖尿病肾病进展中具有潜在作用。血清鸢尾素有望成为糖尿病肾病的预后生物标志物，有待进一步验证。
