Alzoughool Foad, Al-Zghoul Mohammad Borhan, Al-Nassan Saad, Alanagreh Lo'ai, Mufleh Dana, Atoum Manar
Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, The Hashemite University, Zarqa, Jordan.
Basic Veterinary Sciences, School of Veterinary Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Vet World. 2020 Oct;13(10):2191-2196. doi: 10.14202/vetworld.2020.2191-2196. Epub 2020 Oct 20.
Irisin, a novel myocyte-secreted hormone, was proposed to mediate some of the beneficial effects of exercise such as browning of adipocytes, thermogenesis, and metabolic homeostasis. Recently, several animals' models' studies have been performed to investigate the therapeutic impact of irisin in several disorders. Several interventional trials used different doses. However, optimum dose was not determined. This systematic review aims to identify the optimal dose of interventional irisin in mice and rat animal models.
Online databases PubMed, Google Scholar, and Springer were systematically searched from 2012 to 2019. The words searched were irisin, irisin and animal model, physical activity, and irisin and irisin dosage. Non-irisin doses, studies, and factors influencing irisin levels were excluded.
Eleven of the total 391 qualifying studies were included. A daily injection of 500 μg/kg irisin may be the optimum dose of effect in mice and rats.
More studies are required to determine the optimum dose of irisin to be used as a therapeutic intervention based on animal model.
鸢尾素是一种新发现的由肌细胞分泌的激素，被认为介导了运动的一些有益作用，如脂肪细胞褐变、产热和代谢稳态。最近，已经进行了几项动物模型研究来探究鸢尾素在几种疾病中的治疗作用。几项干预试验使用了不同剂量。然而，最佳剂量尚未确定。本系统评价旨在确定在小鼠和大鼠动物模型中进行干预的鸢尾素的最佳剂量。
对2012年至2019年的在线数据库PubMed、谷歌学术和施普林格进行了系统检索。检索词为鸢尾素、鸢尾素与动物模型、身体活动以及鸢尾素与鸢尾素剂量。排除非鸢尾素剂量、研究以及影响鸢尾素水平的因素。
总共391项符合条件的研究中纳入了11项。每日注射500μg/kg鸢尾素可能是对小鼠和大鼠有效的最佳剂量。
需要更多研究来确定基于动物模型将鸢尾素用作治疗干预的最佳剂量。
