Makhlouf Jana, Daoud Khatoun Wassim, Boustany Michel, Chebat Alissa, Ghanem Mohamad, Nemr Rita
Department of Internal Medicine, Gilbert & Rose-Marie Chagoury School of Medicine, Lebanese American University, Byblos, Lebanon.
Department of Endocrinology, Lebanese American University Medical Center-Rizk Hospital (LAUMCRH), Beirut, Lebanon.
AACE Endocrinol Diabetes. 2025 Apr 22;12(2):89-92. doi: 10.1016/j.aed.2025.04.004. eCollection 2025 Jul-Aug.
BACKGROUND/OBJECTIVE: Pituitary apoplexy (PA) is a rare and life-threatening emergency that remains prone to misdiagnosis, especially in pregnancy. Few cases of gestational PA have been reported in the literature.
This study reports a case of a 26-year-old woman presenting at 35 weeks of gestation with PA.
Initial presentation included severe headache, blurry vision, and dizziness, and conservative medical management was opted. This included stress-dose hydrocortisone, cabergoline, and levothyroxine, followed by cesarean delivery at 36 weeks of gestation. The patient retrieved normal pituitary function, except for persistent amenorrhea 2 years after.
This is the first case of isolated persistent hypogonadotropic hypogonadism following PA in a pregnant patient and opens the discussion on the variety of potential complications of this condition.
背景/目的:垂体卒中(PA)是一种罕见且危及生命的急症,仍然容易误诊,尤其是在孕期。文献中报道的妊娠合并垂体卒中病例很少。
本研究报告了一例26岁女性在妊娠35周时发生垂体卒中的病例。
初始症状包括严重头痛、视力模糊和头晕,选择了保守药物治疗。这包括应激剂量的氢化可的松、卡麦角林和左甲状腺素,随后在妊娠36周时进行剖宫产。患者恢复了正常的垂体功能,但2年后仍持续闭经。
这是首例妊娠患者垂体卒中后出现孤立性持续性低促性腺激素性性腺功能减退的病例,并开启了关于该疾病各种潜在并发症的讨论。