Schwarz Evan S, Dicker Frank, Lothet Emilie, Spungen Hannah, Levine Michael
Division of Medical Toxicology, Department of Emergency Medicine, University of California, Los Angeles, California, USA.
Division of Medical Toxicology, Department of Emergency Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Mo Med. 2025 Jul-Aug;122(4):329-333.
The illicit opioid supply is increasingly adulterated with novel synthetic opioids such as nitazenes. Nitazenes are very potent opioids and are increasingly associated with opioid overdoses and deaths. Despite their potency, nitazenes are reversed by naloxone. Given the high risk of overdose associated with these agents, improvements in the delivery of addiction care and naloxone distribution are needed to prevent morbidity and mortality from nitazenes and other novel opioids.
非法阿片类药物供应越来越多地被新型合成阿片类药物（如氮杂环庚三烯类）掺杂。氮杂环庚三烯类是非常强效的阿片类药物，并且越来越多地与阿片类药物过量及死亡相关联。尽管它们效力很强，但氮杂环庚三烯类可被纳洛酮逆转。鉴于与这些药物相关的过量用药高风险，需要改进成瘾护理服务的提供以及纳洛酮的分发，以预防因氮杂环庚三烯类和其他新型阿片类药物导致的发病和死亡。
